摘要
目的结合临床高脂血症的分类,对大鼠实验性高脂血症模型进行分析,为更合理地选择高脂血症动物模型提供依据。方法采用高脂饲料喂养法建立大鼠高脂血症模型。观察喂养30d后大鼠体重、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)的变化。结果高脂饲料组大鼠体重比正常对照组低,但差异无显著性(P>0.05);血清TC明显高于对照组,差异有非常显著性(P<0.01);TG、HDL-C明显低于对照组,差异有显著性(P<0.05、P<0.01)。结论高脂膳食不一定导致体重增加;高脂饲料喂养法所建立的大鼠高脂血症模型只符合高胆固醇血症和低高密度脂蛋白血症的特征,其是否只适用于高胆固醇血症和低高密度脂蛋白血症的研究,而不适用于高甘油三酯血症和混合型高脂血症的研究,有待进一步实验证实。
Objective To experimentally observe the effect of ohigh fat diet on hyperhpidemia in rats. Methods Rats were fed by high fat diet for establishment of hyperhpidemia models .The levels of total cholesterol （TC）, triglyceride （TG）,high density lipoprotein （HDLC）,and body-weight of the rats of hyperlipidemia model group were determined. Results The body-weight of rats in hyperlipidemia models group was lower than that of the control group, without showing significant difference （P〉0.05）. The level of TC was higher than that of the control group （P〈0.05）. The levels of TG and HDL-C were lower significantly than that of the control group（P〈0.05, P〈0.01 ） . Conclusion High fat diet might not lead to a rise of body-weight.The hyperlipidemia rat models established by feeding high fat diet are suitable for researches of hypereholesteremia and hypohpoproteinemia with high-density lipioprotein,not suitable for study on hypertriglycefidemia and mixed hyperhpoidemia.
出处
《中国热带医学》
CAS
2010年第3期324-325,共2页
China Tropical Medicine
