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多西他赛联合放射治疗中晚期食管癌的疗效观察 被引量:1

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摘要 目的 探讨多西他赛联合放射治疗中晚期食管癌的疗效和毒副反应。方法3年间收治不宜手术的局部中晚期食管癌患者80例,采用传统的常规分割放疗,2Gy/次,5次/周,总剂量60Gy-64Gy。放疗同时多西他赛化疗,40mg每周一次,共5次-6认,多西他赛总量200mg-240mg。结果完全缓解30例(37.5%),部分缓解36例(45.0%),无缓解14例(17.5%),总有效率为82.5%。1、2、3年生存率分别为75.1%、39.0%和26.6%。毒副反应主要表现为Ⅰ级-Ⅱ级急性放射性食道炎、急性放射性气管炎和Ⅰ级骨髓抑制。结论多西他赛联合放射治疗局部中晚期食管癌疗效较好,毒副反应轻,患者能够耐受。
出处 《实用肿瘤学杂志》 CAS 2010年第1期68-69,73,共3页 Practical Oncology Journal
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