摘要
目的:观察中药复方对去势动脉粥样硬化大鼠血清雌激素(E2)、C-反应蛋白(CRP)、白介素-6(IL-6)的作用。方法:将64只3月龄SD未孕雌鼠随机分为对照组(假手术,普通饮食)、模型组(卵巢切除、高脂饮食)、西药组(卵巢切除、高脂饮食、雌激素灌胃)、中药组(卵巢切除、高脂饮食、中药灌胃),12周后检测动物血清E2、CRP、IL-6水平。结果:中药复方可升高去势动脉粥样硬化模型大鼠血清E2水平,降低血清CRP、IL-6水平。结论:该中药复方可能具有抑制动脉粥样硬化形成过程中炎症启动和致炎因子激活的作用,可用于防治绝经后动脉粥样硬化性疾病。
Objective： To observe the effect of Chinese herbal compound on serum levels of estrogen, C - reactive protein （CRP） and interleukin -6 （IL -6） in rats with atheroselerosis. Methods： 64 non - pregnant SD female rats aged 3 months were divided into 4 groups randomly： control group （sham -operation, general diet）, model group （oophorectomy, high fat diet）, western medicine group （oo- phorectomy, high fat diet, gastric perfusion of estrogen） and Chinese medicine group （oophorectomy, high fat diet, gastric perfusion of Chinese herbal compound）, then the serum levels of estrogen, CRP and IL-6 were detected after 12 weeks. Results： Chinese herbal compound increased the serum estrogen level and reduced the serum levels of CRP and IL -6 in rats with atherosclerosis. Conclusion： Chinese herbal compound may inhibit the start of inflammation and activation of proinflammatory factors in atheroselerosis, which can be used to prevent and treat postmenopausal atheroscterosis.
出处
《中国妇幼保健》
CAS
北大核心
2010年第6期827-829,共3页
Maternal and Child Health Care of China
基金
广东省科技计划项目资助〔20090315〕
关键词
中药复方
去势
动脉粥样硬化
雌激素
C-反直蛋白
白介素-6
Chinese herbal compound
Oophorectomy
Atherosclerosis
Estrogen
C - reactive protein
Interleukin - 6
