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学龄前单纯性肥胖儿童血清瘦素、胰岛素及性激素水平 被引量：17

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摘要 目的:探讨学龄前单纯性肥胖儿童血清瘦素(Leptin)、胰岛素(Ins)、胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、胰岛素样生长因子结合蛋白-3(IGF-BP3)、雌二醇(E2)和睾酮(T)水平,为单纯性肥胖儿童的早期干预提供理论依据。方法:对122例学龄前单纯性肥胖儿童及61例正常儿童血清Leptin、Ins、IGF-Ⅰ、IGF-BP3、E2和T水平进行测定。结果:学龄前单纯性肥胖儿童血清Leptin、Ins、IGF-Ⅰ、IGF-BP3和E2水平明显高于正常对照组(P均<0.001),两组间睾酮水平差异无统计学意义(P>0.05);肥胖女童血清E2水平明显高于肥胖男童(P<0.01),但Leptin、Ins、IGF-Ⅰ、IGF-BP3和睾酮水平肥胖男女童之间差异无统计学意义(P均>0.05);大年龄组(5～6岁)肥胖儿童血清Leptin、Ins、IGF-Ⅰ、IGF-BP3、E2和睾酮水平明显高于小年龄组(2～4岁)肥胖儿童(P均<0.05)。结论:学龄前单纯性肥胖儿童存在高瘦素血症、高胰岛素血症和肥胖女童的高雌激素血症,是肥胖儿童未来糖尿病、心血管疾病、性早熟等危险因素。
作者 宋媛 朱庆庆 汪宪平 徐华英 陆艳红
机构地区 江苏省苏州市母子医疗保健中心
出处 《中国妇幼保健》 CAS 北大核心 2010年第6期765-767,共3页 Maternal and Child Health Care of China
基金 苏州市科技局自然科学项目基金资助〔SZD0624〕
关键词 单纯性肥胖 学龄前儿童 瘦素 胰岛素 性激素
分类号 R725.9 [医药卫生—儿科]
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参考文献14

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二级参考文献30

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共引文献13

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引证文献17

二级引证文献120

中国妇幼保健
2010年 第6期

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