摘要
以海藻多糖与植物膳食纤维为主要材料,形成一种海藻多糖复合胶(APPC),采用传统硬壳空心胶囊生产的浸沾成型方法,对该复合胶的成膜性能进行了研究。结果表明,当APPC中海藻多糖和植物纤维素的配比度为8:92,成膜胶液的成膜温度在44—48℃,并在该温度下平衡反应0.5—1.5h时,成膜效果较好;形成的APPC膜硬壳空心胶囊的崩解时间为8min;体外药物溶出试验表明APPC膜布洛芬胶囊剂的溶出速率较动物明胶膜相对缓慢,但在30min时的药物溶出度为98.29%,符合国家标准。
Algal polysaccharide composite gel is a type of plant gel containing mainly algal polysaccharide extracted from marine Rhodophyte and plant cellulose,and an important material in pharmaceutical industry.To improve the film-formation performance and determine optimal technical parameters,dissolution temperature,gel ingredient,dissolution equilibrium time,and viscosity variation were studied.Algal polysaccharide empty capsules were produced in immersion shaping technique as well as conventional gelatin capsulation.Performance and characteristics of disintegration and dissolution rate(ibuprofen as standard drug)of algal polysaccharide composite film were compared and evaluated with those of gelatin film.
作者
吴佩
张秀梅
李婷
袁毅
韩丽君
WU Pei;ZHANG Xiu-Mei;LI Ting;YUAN Yi;HAN Li-Jun(Ocean University of China,Qingdao,266003;Institute of Oceanology,Chinese Academy of Sciences,Qingdao,266071)
出处
《海洋与湖沼》
CAS
CSCD
北大核心
2010年第1期148-153,共6页
Oceanologia Et Limnologia Sinica
基金
国家高技术研究与发展计划(863计划)项目:2007AA091604号
中国科学院知识创新工程项目:KZCX2-YW-209号
关键词
植物复合胶
成膜性
空心胶囊
药物溶出度
Vegetable composite gel
Film-formation
Hard shell capsules
Dissolution
