摘要
目的:了解我院严重药品不良反应(ADR)发生情况与特点,促进合理用药。方法:对我院2008年收集到的215例严重ADR报告,按ADR因果关系判别标准进行分析、评价。结果:严重ADR的发生与性别、年龄无关;口服药物发生最多,其次是静脉滴注;涉及药品21大类,引起ADR例数最多的是抗感染药,共101例(28.21%),其次为解热镇痛抗炎药与抗风湿药,共46例(12.85%),再者为中药,42例(11.73%);ADR累及器官或系统以皮肤及其附件损害为主,共73例(33.49%),其次为肝脏损害,共70例(32.11%);在215例严重ADR中,好转160例,治愈54例,有后遗症1例。结论:严重ADR的发生与多种因素有关,应增强合理用药意识,以减少和避免严重ADR的发生,保障药物治疗安全、有效。
OBJECTIVE： To study the status quo and features of serious ADR case in our hospital in order to improve the rational use of drug. METHODS： A total of 215 cases of serious ADR collected in our hospital in 2008 were evaluated and analyzed statistically, according to causality of ADR criteria. RESULTS： Sex and age have nothing to do with serious ADR. The ADR were predominantly induced by antimicrobial drugs accounting for 28.21% （n= 101 ）, followed by antipyretic, analgesics and anti-inflammatory drugs and antirheumatic 12.85% （n=46） and TCM preparation 11.73% （n=42）. Organs and systems involved in ADR were characterized by the damage of skin and its appendants （33.49%, n= 73）, followed by liver lesion in 70 cases （32.11% ）. 160 improved cases, 54 cured cases and 1 sequela cases were include in 215 cases of serious ADR reports. CONCLUSION： Several factors result in serious ADR, so rational use of drug should be enhanced to reduce and avoid occurrence of ADR and guarantee the safety and effectiveness of drug therapy.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第6期529-531,共3页
China Pharmacy
