摘要
目的考察市售不同厂家丙戊酸钠片的溶出度。方法采用转篮法对不同厂家的丙戊酸钠片进行体外溶出度测定,并进行溶出参数方差分析。结果所有厂家产品体外溶出度均符合《中国药典》2005年版的规定,但溶出参数各不相同。结论经统计学处理,不同厂家丙戊酸钠片抽检品的溶出参数有显著性差异(P<0.01)。
Aim To investigate the dissolubility of commercial sodium valproate tablets from different manufacturers. Methods The in vitro dissolubility of different kinds of commercial sodium valproate tablets was determined by basket method and the dissolution parameters were analyzed with variance analysis method. Results The in vitro release rate of different kinds of sodium valproate tablets fit to the request of CHP 2005, but the dissolution parameters were different. Conclusion The statistical results indicate that there are significant differences among products from different factories （P 〈 0.01 ）.
出处
《安徽医药》
CAS
2010年第1期43-44,共2页
Anhui Medical and Pharmaceutical Journal
