摘要
目的观察姜黄素胶囊治疗慢性心力衰竭(CHF)的临床疗效及对TNF-α及脂联素水平的影响。方法将72例CHF患者按住院顺序随机分为2组:对照组予常规西医治疗,治疗组在此治疗基础上加服姜黄素胶囊,2组疗程均为6个月。治疗1个月后采集血标本,用酶联免疫吸附法(ELISA)检测TNF-α、脂联素水平;治疗6个月后对患者的心功能进行观测并记录。结果2组治疗后血浆TNF-α、脂联素浓度均较治疗前明显降低(P均<0.01);但治疗组较对照组降低更明显(P<0.05)。心脏超声示治疗后2组均有不同程度改善,但2组间比较无显著性差异。结论姜黄素胶囊可能通过降低血浆中脂联素及TNF-α浓度起到防止血管、心肌重构的作用。
Objective It is to observe the clinical curative effect of Curcumin capsule on chronic heart failure （CHF） and the effect on the levels of TNF - α and adiponectin. Methods 72 patients with CHF were randomly divided into two groups according to their hospitalization sequence. Control group was given normal western medicine, treatment group was added with Curcumin capsule on the basis of treatment above. Both of the treatment courses were six months. After one month＇s of treatment, blood collection was gotten to determine the levels of TNF - α and adiponectin by ELISA. After six months＇ treatment, heart function of the patients were observed and recorded. Results The contents of plasma TNF- α and adiponectin after treatment were significantly lower than that before treatment in both groups （P〈 0.01 ）, and the contents in treatment group decreased more than that in control group （P 〈 0.05）. Heart super .sound showed that heart function im- proved more or less in both groups, but no significant difference was found. Conclusion Curcumin capsule can prevent the reconstruction of blood vessel and heart muscle possible by decrease the contents of plasma TNF- α and adiponectin.
出处
《现代中西医结合杂志》
CAS
2010年第4期395-396,398,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
