摘要
目的探讨60岁以上Ⅲ期非小细胞肺癌同步放化疗与单纯放疗的疗效及不良反应。方法105例不能手术或拒绝手术治疗的患者,分为放化组52例,单放疗组53例。观察2组的近期疗效、不良反应和1年及2年生存率。结果放化组与单纯放疗的总有效率分别为:90%、75%(P<0.05)。放化组的1年(79%)及2年(54%)的生存率均比单放组(分别为:60%;40%)高,1年生存率比较差异有统计学意义。放化组的骨髓抑制、放射性肺炎及食管炎的发生率均明显比单纯放疗组高(差异均有统计学意义)。结论同步放化疗对老年肺癌的近期疗效及生存率均有一定的提高。对于体质差的老年肺癌患者进行同步放化疗可能会造成较大的损伤,需要权衡利弊。
Objective To evaluated the differences of effect and side reaction between concurrent chemotherapy plus radiotherapy （RT） and RT alone in elderly patients with stage Ⅲ non-small cell lung cancer （NSCLC）. Methods One hundred and five elderly patients（≥60 old years） with NSCLC were randomized into two groups： 53 patients received RT alone, and 52 patients received concurrent chemotherapy plus RT. Results The total effective rate were 75% and 90% for RT alone group and concurrent chemotherapy plus RT group （P〈0.05）. The 1-year and 2-year survival rates were 60% and 40% in RT alone group, 79% and 54% in concurrent chemotherapy plus RT group. There was significant difference between two groups in 1-year survival rate. Patients who received concurrent chemotherapy plus RT experienced significantly greater severe radiation pneumonitis and granulopenia compared with patients who received RT alone. Conclusion Elderly patients with NSCLC gain in a certain degree advantage of total effective rate and 1-year survival rate form concurrent chemotherapy plus RT, but this benefits came at the cost of side reaction.
出处
《实用医技杂志》
2010年第1期19-21,共3页
Journal of Practical Medical Techniques
关键词
癌
非小细胞肺
老年人
放射疗法
抗肿瘤联合化疗方案
Carcinoma, non-small cell lung
Aged
Radiotherapy
Antieoplastic combined chemotherapy protocols
