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上皮钙黏附素在结直肠癌中的表达及临床意义

Expression of E-cad in Colorectal Cancer and Its Clinical Significance
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摘要 目的研究结直肠癌相关的上皮钙黏附素(E-cadherin,E-cad)在不同结直肠黏膜中的表达及其与结直肠癌各种临床病理因素之间的关系。方法标本来源于癌组织手术切除标本。免疫组织化学染色法检测E-cad,比较分析E-cad在不同结直肠癌组织中的表达。结果随着结直肠癌浸润深度加深,E-cad膜表达缺失率升高,淋巴结转移组表达缺失率高于非淋巴结转移组。结论E-cad表达可能参与结直肠癌的发生,并与结直肠癌浸润转移有密切关系。 Objective To evaluate the expression of colorectal cancer related E-cadherin（E-cad） in different colorectal mucosa and the relationship with the hispathology of colorectal cancer.Methods The samples were obtained from colorectal carcinoma resection specimens.The expression of E-cad was assayed by using immunohistochemical staining,compared and studied with the expression of E-cad in different colorectal carcinoma.Results The results showed the FE-cad expression were increased markedly in colorectal cancer group as compared with adenomas and normal mucosa group.And the E-cad positive rate was related to the staging of carcinoma.and were in accored with lymphanode metastasis group.Conclusion Overexpression of E-cad may be involved in the oncogenic potential of colorectal cancer and may be concerned with the invasion and metastasis of colorectal carcinoma.
作者 牛宏立 王万里
机构地区 洛阳东方医院
出处 《河南科技大学学报（医学版）》 2009年第4期251-253,共3页 Journal of Henan University of Science & Technology:Medical Science
关键词 上皮钙黏附素 结直肠癌 免疫组化 E-cadherin（ E-cad） colorectal cancer immunohistochemistry staining
分类号 R735.34 [医药卫生—肿瘤]
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参考文献12

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二级参考文献7

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河南科技大学学报（医学版）
2009年 第4期

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