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上皮钙黏附素及β-连接素在大肠癌中的表达及其临床意义

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摘要 目的探讨上皮钙黏附素(E-cd)及其相关蛋白β-连接素在大肠癌中的表达及其意义。方法应用免疫组化S-P法检测E-cd及β-catenin在45例大肠癌中的表达。结果在大肠癌中,E-cd、β-catenin表达与肿瘤分化程度、浸润程度、生长方式有密切相关;E-cd与淋巴结转移无关,而β-catenin与淋巴结转移有密切相关。结论E-cd、β-catenin的表达水平可以作为评价大肠癌的生物学特性,预测大肠癌转移潜能的参考指标。
作者 陆爱权 覃宗升 刘景龙
机构地区 武警广西总队医院
出处 《广西医学》 CAS 2007年第8期1168-1169,共2页 Guangxi Medical Journal
关键词 大肠癌 免疫组织化学S-P法 上皮钙黏附素 Β-连接素
分类号 R735.34 [医药卫生—肿瘤]
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参考文献8

  • 1Ozawa M, Baribault H, Kemler R. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species [ J ]. EMBO J, 1989,8 (6):1 711-1 717.
  • 2Katagiri A, Watanabe R, Tomita Y. E-cadherin expression in renal cell cancer and its significance in metastasis and survival [ J ]. Br J Cancer, 1995,71 ( 2 ) : 376 - 382.
  • 3Shibamoto S, Hayakawa M ,Takeuchi K, et al. Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells[ J]. Cell Adhes Commun, 1994,1 ( 4 ) : 295 - 305.
  • 4Papkoff J. Regulation of complexed and free catenin pools by distinct mechanisms : Differential effects of Wnt-1 and sre [ J ]. J Biolchem, 1997,272 (7) :4 536 -4 543.
  • 5彭亦凡,孙大龙,顾晋.β-catenin在结直肠癌中的表达及生物学意义[J].中华普通外科杂志,2006,21(4):278-280. 被引量：2
  • 6李刚,王万里,魏莉.E-cadherin、β-catenin、FAK在大肠癌的表达及其意义[J].肿瘤防治研究,2005,32(9):542-544. 被引量：11
  • 7Takayama T,Shiozakl H,Shibanoto S,et al. β-catenin expression in human Cancers[ J ]. Am J Pathol, 1996,148 ( 1 ) :39 - 46.
  • 8Oyama T, Kanai Y, Ochiai A, et al. Atruncated beta-catenin disrupts the interaction between E-eadherin and alpha-catenin : a cause of loss of intercellular adhesiveness in human cancer cell lines [ J ]. Cancer Res,1994,54(42) :6 282 -6 287.

二级参考文献18

  • 1Maruyama K, Ochiai A, Akimoto S, et al. Cytoplasmic betacatenin accmnulation as a predictor of hematogenous metastasis in human colorectal cancer[J]. Oncology, 2000,59 (4) : 302-309.
  • 2NigamAK, SavageFJ, Boulos PB, et al. Loss of cell-cell and cellmatrix adhesion molecules in colorectal cancer[J]. Br Cancer,1993,68(3) :507-514.
  • 3Gunther K,Brabletz T,Kraus C, et al. Predictive value of nuclear beta - catenin expression for the occurrence of distant metastases in rectal cancer [J ]. Dis Colon Rectum, 1998, 41(10): 1256-1261.
  • 4Dorudi S, Hanby AM,Poulsom R,et al. Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome[J]. Br J cancer, 1995,71 (3) :614-616.
  • 5Withers BE, Hanks SK, Fry DW. Correlations between the expression phosphotyosine content and enzymatic activity of focal adhesion kinase, PP125FAK, in tumor and nontransformed cell[J]. Cancer Biochem Biophys, 1996,15(3): 127-139.
  • 6Ayaki M, Komastu K, Mukai M, et al. Reduced expression of FAK in liver metastases compared with matched primary human colorectal adenocarcinoma [J ]. Clin Cancer Res, 2001,7(100) :3106-3112.
  • 7Avizienyte E,Wyke AW. Scr-induced deregulation of E-cadherin in colon cancer cdlls requires integrin signaling[J]. Nat Cell Biol, 2002,4 (8) : 632-638.
  • 8Pennisi E.How a growth control path takes a wrong turn to cancer.Science,1998,281:1438-1441.
  • 9Heinrich BK,Masanori U,Sakae N,et al.Expression level of Wnt signaling components possibly influences the biological behavior of colorectal cancer in different age groups.Exp Mol Pathol,2004,76:224-233.
  • 10Cowin P,Rowlands TM,Hatsell SJ.Cadherins and catenins in breast cancer.Curr Opin Cell Biol,2005,17:499-508.

共引文献11

广西医学
2007年 第8期

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