摘要
目的：揭示血管生成与胃癌发展和预后之间的关系。方法：应用免疫组织化学法和抗人因子Ⅷ相关抗原（ＦⅧＲＡｇ）的抗体标记５６例人胃癌组织中的微血管，检测微血管密度（ＭＶＤ），并分析其与胃癌组织学分级、浸润深度、生长方式、淋巴结转移、远处转移和预后的关系。结果：ＭＶＤ与胃癌浸润深度（Ｐ＜０．０１）、淋巴结转移（Ｐ＜０．０１）和远处转移（Ｐ＜０．０５）密切相关，而与组织学分级和生长方式无关（Ｐ＞０．０５）；ＭＶＤ≥４３的胃癌患者５年生存率较低。结论：血管生成对胃癌的发展具有一定作用。
Purpose To elucidate the relationship between angiogenesis and progression of human gastric carcinoma (GC). Methods Microvessel density (MVD) was determined by immunohistochemical staining in gastric carcinoma tissues with anti human Factor Ⅷ related antigen (F Ⅷ RAg) antibody, and the relation between MVD and histologic types, depth of invasion, growth pattern, lymph node metastasis, distant metastasis and prognosis was analyzed. Results The value of MVD was correlated with depth of invasion ( P< 0 01), lymph node metastasis ( P< 0 01) and distant metastasis ( P< 0 05). It was not significantly related to the histologic type and growth pattern of GC. The 5 year survival rate was significantly lower in patients of GC with MVD≥43. Conclusion Angiogenesis have an important role in the progression of GC. MVD may be a good prognostic indicator for patients with GC.
出处
《临床与实验病理学杂志》
CAS
CSCD
1998年第4期334-336,共3页
Chinese Journal of Clinical and Experimental Pathology
关键词
胃肿瘤
血管生成
肿瘤侵润
肿瘤转移
预后
stomach neoplasms
angiogenesis
microvessel density
neoplasm invasiveness
neoplasm metastasis
prognosis
