摘要
目的探讨Survivin在胃癌中的表达及其与胃癌临床病理特征及预后的相关性。方法用免疫组织化学方法检测85例胃癌标本Survivin的表达,分析其表达与临床病理特征及预后之间的关系。结果Survivin在本组病例中表达的阳性率为37.65(32/85),Survivin的表达与肿瘤分化程度、淋巴结转移、肿瘤侵润深度及病理分期等病理特征无显著相关性(P>0.05);年龄≥60岁的患者Survivin表达的阳性率高于年龄小于60岁的患者,但差异无统计学意义(P>0.05);在Ⅰ、Ⅱ期病例中Survivin的表达与生存之间的关系无统计学意义(P>0.05),而Ⅲ期患者中Survivin阴性表达的患者2年累积生存率高于阳性表达的患者(P<0.05)。结论Survivin的表达与胃癌临床病理特征之间无相关性,在Ⅲ期胃癌患者中Survivin阳性表达是预后的不利因素。
Objective To evaluate the correlation between Survivin expression in gastric cancer and it＇s pathological characters and evaluate the role of Survivin in prognosis of patients with gastric cancer. Metheds Survivin expression in the gastric cancer tissues were investigated by immunohistochemistry in 85 cases. The relationship between Survivin expression in the maligant tissue and patients＇ pathological characters and survival was evaluated. Results The positivity rate of Survivin expression was 37.65 % （32/85） in this group. Survivin expression didn＇ t correlate with the patients＇ pathological characters, such as differentiation,lymph node , depth of invasion and stage （P 〉0.05）. Survivin expression in older patients（≥60 years） was higher than that in younger patients（ 〈 60 years） . But it wasn＇t significant （P 〈 0.05） . The expression of Survivin did not correlate with survival in stage Ⅰ and stage Ⅱ cases. But in stage Ⅲ cases, the 2-year cumulative survival of patients with Survivin negative expression was longer than the positive patients （P〈0.05）. Conclusion Survivin expression in the gastric cancer isn＇t correlative with pathological characters . It was an adverse prognosis factor in stage Ⅲ cases.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2006年第3期431-434,共4页
Suzhou University Journal of Medical Science
关键词
胃癌
SURVIVIN
预后
gastric carcinoma
survivin
prognosis factor
