摘要
目的探讨Ｐ１６蛋白表达在食管癌中的临床意义。方法应用免疫组织化学Ｓ－Ｐ法研究了６１例食管癌组织标本中Ｐ１６蛋白表达与食管癌临床病理特征及预后的关系，以及与增殖细胞核抗原（ＰＣＮＡ）的关系。结果Ｐ１６蛋白阳性表达率为４４．３％，其表达与浸润程度、有无淋巴结转移在统计学上无差异（Ｐ＞０．０５），与分化程度、ＴＮＭ分期有关（Ｐ＜０．０５），与ＰＣＮＡ之间存在相关（Ｐ＜０．０１），与术后肿瘤有无转移、复发在统计学上有差异（Ｐ＜０．０５），Ｐ１６阳性表达组的术后生存时间明显高于阴性组（Ｐ＜０．０１）。结论食管癌组织中Ｐ１６蛋白表达对细胞增殖起负性调控作用，检测其表达有助于对食管癌患者预后的判断。
Objective To study the expression of P16 protein and its clinical significance in esophageal carcinoma. Methods The expression of P16 protein and PCNA in 61 esophageal carcinoma tissues were examined by SP immunohistochemical method. Results The positive rate of P16 protein in esophageal carcinoma was 44.3 percent(27/61). Its expression had a relation with different degree,TNM stage (P<005), and no relation with tumor position, length,pathologic tumor(PT) category,pathologic lymph node(PN) category(P>0.05). Its expression had a negative relation with PCNA expression (P<0.01), associated with tumor metastasis,recurrence after surgery (P<0.05). Survival time after surgery with positive expression of P16 protein was obviously longer than that with negative expression (P<0.01). Conclusion The results suggest that P16 protein might play a negative regulation role in cell proliferation. It might be valuable in evaluating prognosis of esophageal carcinoma.
出处
《中国胸心血管外科临床杂志》
CAS
1998年第3期151-154,共4页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
