摘要
为了研究表皮生长因子(epidermal growth factor,EGF)与胆脂瘤之间的关系,利用免疫组化SLAB法,对18例中耳胆脂瘤和8例外耳道正常皮肤的EGF受体进行了检测.结果显示EGF受体在胆脂瘤的表面强于皮肤,表明在胆脂瘤内有EGF受体的存在和调节异常,进—步证实了胆脂瘤上皮的过度增殖性,同时也表明胆脂瘤的过度增殖与EGF有关.
A monoclonal antibody with defined specification for an epidermal growth factor(EGF) receptor was used to stain the epithelia of the external auditory meatus and cholesteatoma.Streptavidin-Peroxidase immunohistological staining kit was used in this study. The distributionof EGF receptor in normal external ear canal skin (8 persons) and middle ear cholesteatoma (18patients ) was compared. The results indicated that the expression of EGF receptors incholesteatoma was stronger than that in skin. The presence of an aberrant regulation, the persis-tence of EGF receptors in cholesteatoma and the hyperprolife-rative character of the cholesteatomaepithelium were suggested. It was confirmed that EGF was related to hyperproliferation ofcholesteatoma.
出处
《海军总医院学报》
1998年第2期142-145,共4页
Journal of Naval General Hospital of PLA
