摘要
①目的探讨肺鳞癌间质血管生成的意义。②方法应用ＦⅧ相关抗原并采用ＳＬＡＢ法对８９例手术切除的肺鳞癌间质内微血管进行了定量检测。③结果癌间质内微血管呈明显的多态性；血管的分布每２００倍视野在癌肿边缘区组织内为５２．４±２３．７个，在癌组织中央区为３０．５±１３．６个，两组间比较差异有极显著性（ｔ＝４．１８，Ｐ＜０．０１）；有淋巴结转移组肺癌血管密度每２００倍视野５０．２±２２．８个，无转移组为３４±１９．１个；有转移组微血管腔面积每２００倍视野为３４５０．４±１４２１．９μｍ２，无转移组为２００１．０±１２０２．０μｍ２，二者在两组间比较，差异均有极显著性意义（ｔ＝３．１７，ｔ＝３．５８，Ｐ均＜０．０１）。④结论肺鳞癌间质内血管生成与肿瘤生长及淋巴结转移有关。
Objective To study the significance of tumor angiogenesis in human squamous cell carcinoma of lung. Method Microvessel quantitation in 89 cases of lung squamous cell carcinoma was done with factor Ⅷ related antigen and SLAB method. Result The morphology of tumor microvessel was obviously various and the microvessel counts of connective tissue adjacent to tumor were significantly higher than that in tumor center( t=4.18,P <0 01). In lymph node netastasis positive carcinoma, the microvessel count was significantly higher than that in node negative carcinoma( t=3.17,P <0 01), and the area of microvessel lumen in node positive group was obviously higher than that in node negative group( t=3.58,P <0 01). Conclusion The results suggested that angiogenesis in squamous cell carcinoma of lung was correlated with the development of carcinoma and the occurrence of metastasis.
出处
《青岛医学院学报》
1996年第2期133-134,共2页
Acta Academiae Medicinae Qingdao Universitatis
关键词
肺肿瘤
鳞状细胞
新生血管
免疫组织化学
lung neoplasm
carcinoma, sqamous cell
neovascularization
immunohistochemistry
image anlysis
