摘要
探讨表皮生长因子受体(epidermal growth factor receptor,EGFR)和含激酶插入区受体(kinase-insert domain-containing receptor,KDR)的表达与胃癌临床病理特征的关系及其临床意义.应用免疫组织化学PV法,检测60例胃癌组织中EGFR和KDR的表达情况,并且分析其与临床病理特征的关系.胃癌组织中EGFR和KDR阳性表达率分别为48.3%(29/60)、63.3%(38/60),二者的阳性表达与浸润深度、淋巴结转移、TNM分期相关(P<0.05),并且存在共表达现象,表达强度呈正相关(rs=0.664,P<0.05).EGFR和KDR在胃癌的进展中起协同作用,为靶向EGFR和KDR生物治疗制剂在胃癌生物治疗中的应用及联合应用提供了一定的理论依据.
To explore the expression of epidermal growth factor receptor （EGFR） and kinase-insert domaincontaining receptor （KDR） in gastric cancer, analyze their relationship with clinicopathologieal features, and discuss their clinical significance. Immunohistochemistry PV method was used to detect the expression of EGFR and KDR in 60 cases of gastric cancer, and the relationship between protein expression and clinic pathological features was analyzed. The positive expression rates of EGFR and KDR were 48.3% （29/60） and 63.3% （38/60） in gastric cancer respectively. The expression rates of both EGFR and KDR were correlated with depth of invasion, lymph node metastasis, and TNM stage （P〈 0.05）. There was coexpression of EGFR and KDR in gastric cancer, furthermore there was a positive correlation between the expression intensity of EGFR and that of KDR（rs=0.664, P〈0.05）. EGFR and KDR have synergistic effect on gastric cancer progression, which lays a theoretical foundation on the single application and the combined application of biologicals targeting EGFR and KDR in gastric cancer biotherapy.
出处
《生命科学研究》
CAS
CSCD
2009年第6期538-541,共4页
Life Science Research
基金
国家自然科学基金资助项目(30972872)
关键词
胃癌
免疫组织化学
表皮生长因子受体
含激酶插入区受体
肿瘤生物治疗
gastric cancer
immunohistochemistry
epidermal growth factor receptor
kinase-insert domain- containing receptor
cancer biotherapy
