摘要
目的研究胃癌高发区不同人群幽门螺杆菌（Ｈｐ）ｃａｇＡ＋亚型感染状况，探讨ＨｐｃａｇＡ＋亚型感染与胃癌高发流行的关系．方法用ＥＬＩＳＡ方法检测了全部受检者的抗Ｈｐ抗体及抗ｃａｇＡ抗体，并用１３Ｃ尿素酶呼吸实验（１３Ｃ－ＵＢＴ）方法检测了７０名儿童Ｈｐ感染状况．结果胃癌高发区成人Ｈｐ感染率为７４７％，儿童Ｈｐ感染率为６８６％；成人ｃａｇＡ＋亚型感染率为６５％，儿童为７１４％．７７名癌症患者的Ｈｐ和ｃａｇＡ＋亚型感染率均为５９７％，其中胃癌患者（ｎ＝３８）Ｈｐ和ｃａｇＡ＋亚型感染率分别为５０％和５５３％，均低于其他癌症患者（ｎ＝３９）的感染率（６９２％和６４１％）．结论胃癌高发区成人、儿童及癌症患者ＨｐｃａｇＡ＋亚型感染率相当高，表明Ｈｐ感染，尤其是ｃａｇＡ＋的Ｈｐ感染与当地胃癌高发有明显的关系．
IM To determine the seroprevalence of Helicobacter pylori (Hp) with cagA+ strain in different population at a high risk area of gastric cancer (GC), and evaluate whether infection of Hp with cagA+ is associated with the development of GC. METHODS Using ELISA to detect IgG and IgA to antiHp and IgG to antiCagA antigen, we examined the total 368 serum samples from Linqu County (mortality of GC=43/100 000). The children were also examined by 13Curea breath test (13CUBT) to confirm Hp infection. RESULTS The Hp seropositive rates of adults and children were 747% and 686%, and cagA+ were 65% and 714%, respectively. However, the seropositive rates of Hp and cagA+ were similar (597%) in 77 cancer patients. CONCLUSION The seroprevalence of Hp with cagA+ strain is significantly high in the population at a high risk area of GC. The infection of Hp with cagA+ may be a key factor of development of GC..
关键词
胃肿瘤/微生物学
螺杆菌.幽门
螺杆菌感染/并发症
stomach neoplasms/microbiology
Helicobacter pylori
Helicobacter infections/complications
