摘要
吸烟是肺气肿的重要危险因素，同时也与多种问质性肺病的发病密切相关。一部分吸烟者肺部影像可以同时存在下肺野纤维化和上肺野肺气肿，目前认为这种临床特征是一种独立的疾病，称作肺纤维化合并肺气肿。这部分患者肺功能表现为肺容积相对正常而弥散能力显著下降．而且肺动脉高压发生率较高。但该病的发病机制不清楚，有效的治疗策略和预后判断有待进一步研究。
Smoking is the principal risk factor for emphysema, and may be also associated with many kinds of interstitial lung diseases. The co-existence of lower lung fibrosis and upper lung emphysema is being increasingly recognized as a distinct clinical entity in some smokers, so called combined pulmonary fibrosis and emphysema（CPFE）. CPFE can be presented by relatively normal lung volume, however, impairment of gas exchange is severe. A high prevalence of pulmonary hypertension is seen in CPFE. The pathogenesis of CPFE is not known, so further studies need to explore effective treatment strategy and prognosis judgement.
出处
《国际呼吸杂志》
2009年第24期1505-1508,共4页
International Journal of Respiration
基金
基金项目：新世纪优秀人才支持计划（NCET06-0156）
关键词
吸烟
肺气肿
特发性肺纤维化
肺纤维化合并肺气肿
Smoking
Emphysema
Idiopathic pulmonary fibrosis
Combined pulmonary fibrosis andemphysema
