摘要
目的探讨单纯特发性肺纤维化（IPF）和肺纤维化合并肺气肿（CPFE）患者的临床差异。方法选取我院2007年8月至2012年8月收治的13例CPFE患者作为观察对象，设为观察组，选择同期13例单纯IPF患者作为对照，设为对照组。对比两组患者的临床资料、PaO2、肺功能、BALF细胞成分等指标和临床用药的差异。结果观察组吸烟患者占92.3%.吸烟指数为（29.7±18. 6）包年，均高于 对照组[53.8%.t=7.89. P〈0.05;（17.8±16.4）包年，t =1.73.P〈0.05J。两组PaO，和肺活 量%pred差异无统计学意义（t值分别为0. 21、1. 29. P值均〉0.0日，观察组FEV，/FVC和DLCO%pred 均低于对照组[（77.9±7.7）%vs （85.6±8. 9） %，t = 2. 36. P 〈 0. 05; （44. 1±12.3） % vs （54.3±16.7） %. t = 1.77， P 〈0. 05J.而肺总量% pred显著高于对照组[（77. 3±12.2） % vs （64.4± 12.4） %. t =2.67. P 〈0. 01]。两组患者BALF所有细胞成分相似，差异均无统计学意义（ P值均〉 0.05） .用药情况基本」致。结论吸烟可能是CPFE患者的重要危险因素.CPFE患者弥散功能显著下降且肺容积异常。
Objective To investigate the clinical differences of idiopathic pulmonary fibrosis （IPF） and combined pulmonary fibrosis and emphysema （CPFE） patients. Methods 13 cases of CPFE patients in our hospital from August 2007 to August 2012 were enrolled as observation group, and 13 cases of simple IPF patients in the same period were selected as control group. The differences of clinical data, PaO pulmonary function, bronchoalveolar lavage fluid （BALF） cell component index, and clinical medication between two groups were compared. Results Smoking patients in observation group accounted for 92. 3% ,smoking index was （29. 7±18. 6） pack years. which were higher than those in control group [53.8% , X＇ = 7. 89. P 〈0. 05; （17： 8 ± 16. 4） pack years. t = 1. 73, P 〈0. 05]. There was no significant difference between two groups in PaO, and vital capacity of expected value （ t = 0. 21, 1. 29, all P 〉 0.05）. FEV, /FVC and DLCO% pred in observation group were lower than those in control group [（ 77. 9 ± 7. 7） % vs （85. 6 ± 8. 9） % , t = 2. 36, P 〈0. 05; （44. ] ± 12. 3） % vs （54. 3 ± 16. 7） % ？ t = 1. 77. P 〈 0.05 J, while the lung volume percentage of predicted value was significantly higher than that in control group [（77. 3± 12.2） % vs （64.4 ± 12.4） %. t = 2. 67, P 〈 0.0] J. There was no significant difference between two groups in BALF cell components （all P 〉 0. 05）. The medication was basically consistent in two groups. Conclusions Smoking is an important risk factor of CPFE patients. In CPFE patients. diffuse function decreases and lung volume is abnormal.
出处
《国际呼吸杂志》
2014年第4期254-256,共3页
International Journal of Respiration
关键词
特发性肺纤维化
肺纤维化合并肺气肿
肺功能
临床差异
Idiopathic pulmonary fibrosis
Comb{ned pulmonary fibrosis and emphysema
Pulmonary function
Clinical differences
