摘要
目的探讨血管内皮生长因子-C（vascular endothelial growth factor—C，VEGF—C）的表达与乳腺癌淋巴结转移的关系。方法应用免疫组化法观察78例乳腺浸润性导管癌组织中VEGF-C的表达情况，评价VEGF-C表达与淋巴结转移及其他临床病理因素的关系。取20例乳腺纤维腺瘤标本做对照。结果78例乳腺浸润性导管癌中52例VEGF—C呈阳性表达，阳性率为67％；对照组仅3例可见VEGF—C弱表达，阳性率为15％。乳腺癌组VEGF—C表达阳性率明显高于对照组，差异有统计学意义（P〈0．01）；乳腺癌腋淋巴结转移组VEGF—C表达阳性者阳性率（78％）明显高于腋淋巴结无转移组（48％），差异有统计学意义（P〈0．05）；VEGF—C表达与患者年龄、肿瘤大小、激素受体、及临床分期之间差异无统计学意义（P〉0．05）。结论VEGF—C与乳腺癌淋巴结转移呈正相关，是乳腺癌重要预后因子。
Objective To investigate the expression of VEGF-C in breast cancer and its relationship with lymph node metastasis. Methods VEGF-C expression was assessed by immunohistochemistry in 78 cases of breast cancer. The relationship between expression of VEGF-C and lymph node status and clinicopathological fea- tures in breast cancer was analyzed. 20 cases of breast fibroadenoma was taken as control group. Results The expression of VEGF-C was significantly higher in breast cancer group than that in fibroadenoma group （P 〈 0.01 ）. VEGF-C was significantly higher it1 axillary lymph node-positive group than that in axillary lymph node- negative group（ P 〈 0.05 ）. No relativity was found between VEGF-C and patient age, tumor size, estrogen receptor status, progesterone receptor status, and clinical stage. Conclusion The high expression of VEGF-C has a relativity with lymph node metastasis of breast cancer and may be important for the breast cancer＇s prognosis.
出处
《中华内分泌外科杂志》
CAS
2009年第6期374-377,共4页
Chinese Journal of Endocrine Surgery
