摘要
目的探讨海带对高脂血症大鼠血脂的调节作用机制。方法雌性Wistar大鼠40只,高脂饲料喂养建立高脂血症动物模型,海带粉饲料喂养干预治疗。血生化法检测大鼠血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)水平及脂蛋白酯酶(LPL)和肝脂酶(HL)的活性。结果海带治疗组动物血清TG和TC水平较治疗前和模型组显著下降(P<0.05)。LDL水平显著低于模型组(P<0.05),而HDL、LPL和HL水平均显著高于模型组(P<0.05)。结论海带可能通过增强LPL和HL的活性,影响TG、TC、LDL和HDL等血脂组分的代谢,而发挥调节血脂水平的作用。
Objective To investigate the regulating effects and mechanism of Laminaria japonica （L. japonica） on serum lipid of hyperlipidemia rats. Methods Forty healthy female Wistar rats were used to establish hyperlipidemia models by feeding fat-rich forage, and the powder of L. japonica was applied as a supplement in forage for test groups. The levels of serum lipid including the triglyceride （TG）, total cholesterol （TC）, low-density lipoprotein （LDL）, high-density lipoprotein （HDL） and the activities of lipoproteinesterase （LPL） and hepatic lipase （HL） were detected by biochemical assay. Results The levels of serum TG and TC in test group decreased significantly than those in pre-treated and model group （P〈0.05）. After treatment with L. japonica powder, the levels of serum LDL were lower and the serum HDL higher than those in the model group （P〈0.05）, The levels of serum LPL and HL in test group were significantly higher than those in the model group （P〈0. 05）. Conclusion L. japonica might play a regulating effects on serum lipid by enhancing the activities of LPL and HL to interfere the metabolism of TG,TC,LDL and HDL.
出处
《中国海洋药物》
CAS
CSCD
2009年第6期1-4,共4页
Chinese Journal of Marine Drugs
基金
国家自然科学基金项目(40976085)
关键词
海带
高脂血症
大鼠
Laminaria japonica
hyperlipemia
rats
