摘要
目的:探讨在心功能正常情况下不稳定心绞痛(UAP)与稳定型心绞痛(SAP)患者血浆N-末端脑钠肽前体(NT-proBNP)浓度的差异,UAP患者血浆NT-proBNP浓度与肌钙蛋白I(cTnI)的相关性。方法:选择住院冠心病心绞痛患者116例,其中SAP54例,UAP组62例(cTnI阳性者32例,阴性者30例),正常对照组35例,测定血浆NT-proBNP、cTnI浓度,比较不同组NT-proBNP浓度,及分析UAP患者NT-proBNP与cTnI的关系。结果:UAP患者血浆NT-proBNP浓度[146.55(53.65,772.55)ngP/L]高于SAP组[47.50(19.23,87.35)ngP/L]和对照组[33.38(14.07,66.60)ngP/L](P<0.01),SAP组血浆NT-proBNP浓度与对照组比较无显著差异(Z值-1.20,P>0.05),且UAP中cTnI阳性组血浆NT-proBNP浓度[646.86(127.85,1181.63)ngP/L]高于cTnI阴性组[91.50(26.54,145.83)ngP/L](Z值-3.96,P<0.01),UAP血浆NT-proBNP浓度与cTnI浓度呈正相关(r=0.57,P<0.05)。结论:UAP血浆NT-proBNP浓度增高,并与cTnI浓度呈正相关;其测定有利于发现心功能正常,但处于高风险的患者。
Objective： To investigate the difference of plasma level of N--terminal ProB--type natriuretic peptide （NT --proBNP） between patients with unstable angina （UAP） and stable angina （SAP） in normal heart function and cor- relation between NT--proBNP level and plasma cardiac troponin I （cTnl）. Methods： A total of 116 patients with angina pectoris were enrolled in this study, including 54 SAP, 62 UAP patients. The UAP patients were divided into cTnI positive group （32 cases） and eTnl negative group （30 cases）. The 30 healthy persons were selected as normol control. The left ventricular ejection fraction （LVEF） in all patients with angina pectoris were 〉45 %. Results： Plasma levels of NT--proBNP were 146.55 （53.65, 772.55）ngP/L, 47.50 （19.23, 87.35） ngP/L, 33.38 （14.07, 66.60） ngP/L in patients with UAP, SAP and normal control respectively, the level of NT-- proBNP was significantly higher in UAP than that in SAP and normal control （P〈0. 01 all） ; there were no significant difference in NT-- proBNP level between SAP and normal control （P〉0.05）. Plasma levels of NT--proBNP were 646.86 （127.85, 1181.63） ngP/L, 91.50 （26.54, 45.83） ngP/L in UAP patients with cTnI （＋） and cTnI （-） respectively, the level of NT--proBNP was significantly higher in UAP patients with cTnl （＋） than that in UAP with cTnI （-） （P〈 0. 051）. NT--proBNP level was positively correlated with cTnI in UAP patients （r=0. 57, P〈0. 05）. Conclusion： The plasma NT-- ProBNP level in UAP patients increase and it positively correlated with cTnI; NT-- ProBNP is associated with the severity of myocardial ischemia although heart function is normal. So must measure the plasma NT-- proBNP to find the CHD patients with high risk.
出处
《心血管康复医学杂志》
CAS
2009年第6期544-547,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
心绞痛
不稳定型
利钠肽
脑
肌钙蛋白Ⅰ
Angina, unstable
Natriuretic petide, braim
Treponin I
Myocardial ischemia
