摘要
目的：探讨糖尿病血液流变性与微循环的关系。方法：检测35例糖尿病患者甲壁微循环、血液流变指标，与35例正常人对照。结果：（1）非胰岛素依赖型糖尿病（NIDDM）组全血高、低切粘度和高、低切还原粘度及血浆粘度均显著高于对照组（P＜0．01～0．001），而胰岛素依赖性糖尿病（IDDM）组上述各粘度指标仅轻度增高（P＞0．05）；（2）糖尿病各组及不同并发症组均有微循环血流减慢，红细胞刚性增高、电泳率降低、聚集性增强，白色微血栓等指标显著异常（P＜0.05～0.001）；（3）NIDDM组及并发症组微血管畸形数增多，管袢长度增加，微血管周围有明显渗出及出血等形态和管周指标的改变（P＜0.05～0.001）。结论：（1）各型糖尿病患者均有不同程度微循环障碍及血液流变性异常。（2）甲襞微循环障碍与血液流变性异常有一定的相关性。
Objective: To investigate on change of hemorheology and nailfold microcirculation in patients with diabetes mellitus. Method: The parameters of hemorhe-ology and nailfold microcirculation in 35 diabetics and 35 healthy Persons forcontrol were determined. Results: (l) The whole blood viscosity and wholeblood reduced viscosity at high and low shear rata and plasma viscosity in NIDDM group were significantly higher than in control group (P<0. 01~0. 001 );in IDDM group, those viscosity parameters were only slighly higher than control group but not significantly (P<0. 05). (2) The RBC rigidity index andthe RBC electrophoresis rate and all paramaters of bloodstream of microcirculation in every DM group and subgroup of diabetics with different complicationswere higher or lower than controls, repectively (P<0. 05~0. 001 ). (3) Theparameters of the capillary loops and Pericapillary at microcirculation in NIDDMgroup and some subgroups of the diabetics with chronic complications were higher or lower than controls, respectively (P<0. 05~0. 001 ). Conclusion: (1)There are abnormal change of hemorheology and microcirculation in every DMgroup. (2) There is a significant relationship between of hemorheology and crocirculation.
出处
《微循环学杂志》
1998年第3期17-18,共2页
Chinese Journal of Microcirculation
关键词
糖尿病
血液流变学
微循环障碍
Diabetes mellitus
Hemorheology
Microcirculation, nailfold
