摘要
加替沙星与茜素红反应可形成配合物,使茜素红的紫外吸光度增强,且加替沙星浓度在0.20~110.00mg.L-1范围内与吸光度呈良好的线性关系,以此为基础,建立了测定加替沙星的新方法.将此方法用于片剂、粉针剂和尿液中加替沙星含量的测定,结果与文献报道的荧光法一致.
A new method for the determination of gatifloxacin（GFLX） has been developed based on the interaction between alizarin red（ARS） and GFLX resulting in an UV absorbance of ARS enhancement at 261 nm.At the same time,the linear relationship between the absorbance intensity and concentration of GFLX was over the range of 0.20~110.00 mg·L-1.The method has been applied for the determination of GTFX in tablet,injection and urine,and the results are very close to those obtained by fluorimetry method reported.
出处
《化学研究》
CAS
2009年第4期91-94,共4页
Chemical Research
关键词
加替沙星
茜素红
紫外分光光度法
测定
gatifloxacin
alizarin red
UV spectrophotometry
determination
