摘要
粘附斑激酶(focal adhesion kinase,FAK)是一类胞质非受体蛋白酪氨酸激酶,属于蛋白酪氨酸激酶(protein tyrosine kinase)超家族,因而也称为PTKⅡ。FAK在细胞信号转导中处于十分重要的位置,它是胞内外信号出入的中枢,介导多条信号通路。FAK可以整合来自整合素、生长因子以及机械刺激等的信号,激活胞内PI3K/Akt、Ras/MAPK等信号通路,调节细胞生长。FAK还与胚胎发育、肿瘤发生与迁移有关。
Focal adhesion kinase （FAK） is a cytoplasmic nonreceptor protein-tyrosine kinase, belonging to the protein tyrosine kinase superfamily,also called as PTK Ⅱ. FAK is essential for the cell signal transduction, participates in many ＂outside-in＂ and ＂in- side-out＂ pathways. FAK can integrate signals from integrin, growth factors and mechanical stress, activate the PI3K/Akt and Ras/ MAPK pathway, and regulate cell growth. Besides, FAK is tightly linked to the embryonic development, tumorigenesis and migration.
出处
《生物技术通报》
CAS
CSCD
北大核心
2009年第12期6-10,共5页
Biotechnology Bulletin
基金
国家自然科学基金(30860191)
国家基础科学人才培养基金(J0730648)
关键词
粘附斑激酶
发育
肿瘤
信号通路
Focal adhesion kinase Development Tumor Signal transduction
