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BCR/ABL嵌合蛋白信号转导研究进展 被引量：3

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摘要 BCR/ABL嵌合蛋白具有较强的蛋白酪氨酸激酶 (PTK)活性 ,可组成性激活Ras/MAPK ,JAK STAT ,PI3 K ,c Myc等细胞内各种信号转导途径 ,从而促进细胞的分裂、改变造血细胞的粘附特性及运动性、降低细胞对凋亡信号刺激的反应性 。
作者 罗军 宋善俊
机构地区 广西医科大学一附院血液科 华中科技大学同济医学院协和医院血液病研究所
出处 《国外医学（生理病理科学与临床分册）》 2003年第4期388-390,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 BCR/ABL 蛋白酪氨酸激酶 信号转导
分类号 R346 [医药卫生—基础医学]
  • 相关文献

参考文献20

  • 1Zhang X, Subrahmanyam R, Wong R, et al. The NH2-terminal coiled-coil domain and tyrosine177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl[ J]. Mol Cell Biol,2001,21 (3) : 840-853.
  • 2Zhang X, Wong R, Hao SX, et al. The SH2 domain of Bcr/Abl is not required to induce a murine myeloprolifemtive disease ; however,SH2 signaling influences disease latency and phenotype [ J ].Blood, 2001,97( 1 ) : 277-287.
  • 3Kashige N, Carpino N, Kobayashi R. Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits BasGAP activity [J]. Proc Natl Aead Sci USA. 2000, 97(5) : 2093-2098.
  • 4Shi CS, Tuscano J, Johnl JH. Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase C, CKR promoting GCKR and SAPK activation[J]. Blood, 2000, 95(3) : 776-782.
  • 5de Groot RP, Raaij makers JA, Lammers JW, et al. STATS activation by BCR-ABL contributes to transformation of K562 leukemia cells[J]. Blood, 1999, 94(3): 1108-1112.
  • 6Sillaber C ,Gesbert F, Frank DA ,et al. STAT5 activation contributes to growth and viability in Bcr/Abl transformed cells [ J ]. Blood,2000, 95(6): 2118-2125.
  • 7Horita M, Andreu EJ, Benito A, et al. Blockade, of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5- dependent expression of Bcl-XI[ J]. J Exp Med, 2000,191 (6) :977-984.
  • 8Jiang X, Lopez A, Holyoake T, et al. Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia [ J ]. Proc Natl Acad Sci USA, 1999,96 ( 22 ) :12804-12809.
  • 9Deininger MW, Vieira S, Mendiola R, et al. BCR-ABL tyrosine kinase activity regulates the expression of multiple genes implicated in the pathogenesis of chronic myeloid leukemia [ J ]. Cancer Res,2000,60 ( 7 ) : 2049-2055.
  • 10Cardone MH, Roy N, Stennicke HR, et al. Regulation of cell death protease caspase-9 by phosphorylation [ J ]. Science, 1998,282(5392) : 1318-1321.

同被引文献24

  • 1李楚芳,曹诚,马清钧.c-Abl与应激损伤调控[J].生物技术通讯,2004,15(4):379-382. 被引量：1
  • 2Lara W, Heiko van der K, Cornelius M, et al. Inhibition of BCR-ABL gene expression by small interfering RNA sensitizes for imatinib mesylate ( STI571 ) [ J ]. BLOOD, 2003,102 : 2236- 2239.
  • 3Monika W, Uta F, Wilhelm W, et al. Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference(RNAi) [J].Oncogene,2002,21 : 5716 - 5724.
  • 4Dimitri S, Leigh F, Aparna S, et al. Specificity of short interfering RNA determined through gene expression signatures [ J ].PNAS, 2003,5 : 6347 - 6352.
  • 5Paul CP, Winer I, Engelke DR. Effective expression of small interfering RNA in human cells. Nat Biotechnol,2002,20(5) :505.
  • 6Dimitri S, Leigh F, Aparna S, et al. Specificity of short interfering RNA determined through gene expression signatures. PNAS, 2003,5:6347.
  • 7Lara W, Heiko van der K, Cornelius M, et al. Inhibition of bcr- abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571). Blood, 2003,102:2236.
  • 8Monika W, Uta F, Wilhelm W, et al. Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference(RNAi). Oncogene, 2002,21: 5716.
  • 9Ghobrial IM, Adjei AA. Inhibitors of the ras oncogene as therapeutic targets. Hematol Oncol Clin North Am, 2002,6(5):1065.
  • 10Duursma AM, Agami R. Ras interference as cancer therapy. Seminars in Cancer Biolotgy, 2003,13:267.

引证文献3

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国外医学（生理病理科学与临床分册）
2003年 第4期

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