摘要
从国产茯苓干燥菌核中分得３β，１６α二羟基羊毛甾７，９（１１），２４（３１）三烯酸（Ⅰ）、３酮基１６α羟基羊毛甾７，９（１１），２４（３１）三烯酸（Ⅱ）和３β乙酰氧基１６α羟基羊毛甾８（９），２４（３１）二烯酸（Ⅲ）３个化合物．化合物（Ⅰ）为首次分得并确证其分子结构，补充了（Ⅱ）的光谱数据，归属了３种类型化合物的碳和特征氢的核磁光谱，总结出其分子的结构特点．用两种反应条件较温和的方法制备出１２种衍生物，测定了ＨＰＬＣ，ＭＳＦＡＢ，ＩＲ，ＵＶ，１ＨＮＭＲ，１３ＣＮＭＲ及１Ｈ１ＨＣＯＳＹ等光谱数据．测定了１２个化合物对人慢性髓样白血病Ｋ５６２细胞的抑制作用和对小鼠Ｔ淋巴细胞增殖影响的生物活性。
Three lanostane triterpenes were isolated from dried sclerotia of Chinese Poria cocos (Schw.)Wolf,They were 3β,16α dihydroxylanosta 7,9(11),24(31) trien 21 oic acid (Ⅰ),3 oxo 16α hydroxylanosta 7,9(11),24(31) trien 21 oic acid(Ⅱ)and 3β O acetyl 16α hydroxylanosta 7,9(11),24(31) trien 21 oic acid (Ⅲ).Compound (Ⅰ) was first isolated,its structure was established.Twelve derivatives were isolated by TLC after treatment with Ph 2CNN or RX under mild condition,their structures were verified by HPLC,MS FAB,UV,IR and NMR spectral data.Eight compounds showed bioactivities to K 562 ,four of (Ⅰ) type were more effective.The compounds showed effects on proliferation of T lymphocytes from mice.
出处
《中国药物化学杂志》
CAS
CSCD
1998年第4期239-244,共6页
Chinese Journal of Medicinal Chemistry
关键词
茯苓
三萜及其衍生物
抗肿瘤
免疫
Chinese Poria cocos
lanostane triterpene derivative
anticancer
immunity
