摘要
为了寻找新型高效低毒的抗真菌药，根据氮唑类抗真菌药物的构效关系和作用机理，设计合成了８个２（取代苯氧基）甲基４（２，４二氟苯基）４（１Ｈ１，２，４三唑１基）甲基１，３二氧戊环类化合物。初步的体外抗真菌活性试验表明，所有的目标化合物对５种常见的深部致病真菌都有不同程度的抗真菌活性，所有目标化合物的活性与克霉唑相当或更高，特别是对白念珠菌、新生隐球菌。
According to the antifungal mechanisms and structure activity relationships of the azole compounds,fifteen 1 (1 H 1,2,4 triazole 1 yl) 2 (2,4 difluorophenyl) 3 substituted phenoxy 2 propanols were designed and synthesized.All of them were confirmed by 1H NMR and elementary analysis.The results of the preliminary antifungal tests in vitro showed that all of the title compounds exhibited mild activities against systematic pathogenic fungi such as Candida albicans,Cryptococcus neoforms,Sporotrichum schenckii and Cladosporium carrionii.
出处
《中国药物化学杂志》
CAS
CSCD
1998年第4期235-238,共4页
Chinese Journal of Medicinal Chemistry
