摘要
目的探讨血糖波动与痛性神经病变患者痛域及疼痛程度的关系。方法对16例痛性神经病变患者采用McGill疼痛评分分为轻中度病变组和重度病变组。对两组患者进行痛阈测定并行动态血糖监测,计算24h平均血糖水平、血糖标准差、血糖波动最大幅度、平均血糖波动幅度,并检测空腹血糖、糖化血红蛋白。结果重度病变组血糖标准差、血糖波动最大幅度、平均血糖波动幅度均显著高于轻中度病变组(P<0.05),且与疼痛评分呈显著正相关关系。两组间平均血糖水平、空腹血糖及糖化血红蛋白无显著差异(P>0.05)。结论血糖波动与痛性神经病变疼痛程度有关,积极控制血糖波动有助于对痛性神经病变的治疗。
Objective To investigate the relationship between blood glucose fluctuation and the pain sensation in patients with painful diabetic neuropathy. Methods The severity of pain in 16 patients with painful diabetic neuropathy was assessed using visual analog scale （VAS）, and according to the results, the patients were divided into mild to moderate pain group and severe pain group. The blood glucose of the patients were monitored continuously for 72 h using a continuous glucose monitoring system, and the MBG, SD, DMMG, MAGE, and AUCPG were obtained with the FBG and HbAIC tested. Results The SD, DMMG, and MAGE of the severe pain group were all significantly higher than those of the mild to moderate pain group （P〈0.05）, and no significant difference was found in MBG, FBG or HbAlc between the two groups. Conclusion The blood glucose fluctuation is associated with the severity of the pain degree, and effective control of the blood glucose fluctuation helps prevent and treat painful diabetic neuropathy.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2009年第10期2104-2106,共3页
Journal of Southern Medical University
关键词
糖尿病
痛性神经病变
血糖波动
疼痛评分
diabetes
painful diabetic neuropathy
blood glucose fluctuation
pain degree
