摘要
目的:通过总结和分析关节软骨损伤修复相关方面的研究,阐述了转化生长因子β、骨形态发生蛋白7在膝关节软骨损伤修复中的价值和作用,为今后临床应用提供重要的参考依据。资料来源:以Articular Cartilage Defects,Transforming Growth Factor-β,Bone Morphogenic Protein-7为检索词,检索science online,ElsecierSD数据库,Springer Link电子期刊网等(1991-01/2009-06);以关节软骨损伤,转化生长因子β,骨形态发生蛋白7为检索词,检索中国知网,万方数据库,清华同方数据库(1991-01/2009-06)。文献检索语种限制为英文和中文。资料选择:纳入与生长因子有关的修复关节软骨损伤的文献,排除重复文献。结局评价指标:①骨折的愈合情况。②骨细胞的增殖情况。③软骨形成的能力。结果:计算机初检得到95篇文献,根据纳入排除标准,对生长因子对尤其是转化生长因子β及骨形态发生蛋白7修复膝关节软骨损伤的文献进行分析。关节软骨损伤在运动员中非常多见,并且关节中的软骨组织修复能力较差。由于一旦损伤即产生永久性病变,且关节软骨损伤的传统治疗方法效果不显著,治疗的困难是运动医学亟待解决的问题。转化生长因子β是调节软骨形成的重要因子,对多种细胞具有刺激或抑制作用。通过提高软骨细胞的敏感性,在骨性关节炎的软骨损伤修复过程中起着中枢的作用,同时对体外软骨细胞的蛋白合成有调节作用,在诱导特殊肉芽组织方面也有重要作用。骨形态发生蛋白7能诱导间充质来源软骨和创面周围软骨产生特异性胶原及黏蛋白,对促进软骨损伤的修复具有明显的作用。结论:转化生长因子β及骨形态发生蛋白7对膝关节软骨损伤有一定的作用,但是二者联合是否会促进关节软骨损伤的修复,有待于今后进一步的实验研究。
OBJECTIVE： To elucidate the role of transforming growth factor-β and bone morphogenetic protein-7 in the reparation of knee cartilage by summarizing related studies, which can provide an important reference for further clinical applications. DATA SOURCES： The science online, EIsecierSD databases, Springer Link electronic journals nets （1991-01/2009-06） was searched using key words of ＂Articular Cartilage Defects, Transforming Growth Factor-B, Bone Morphogenic Protein-7＂; simultaneously, the CNKI, Wanfang database, Tsinghua Tong Fang database （1991-01/2009-06） was searched with the same Chinese key words. Literature search was limited to English and Chinese languages. DATA SELECTION： Literature addressing repairing articular cartilage damage with growth factors was included, and the repeated papers were excluded. MAIN OUTCOME MEASURES： ① Fracture healing. ②Osteocyte proliferation. ③Capacity of chondrification. RESULTS： Received 95 computers seized in early literature, according to inclusion exclusion criteria, literature underlying growth factor, in particular the growth factor transforming growth factor-B and bone morphogenetic protein-7 in repairing knee cartilage damage was analyzed. Articular cartilage injury, with poor repair capacity, is more common in athletes. As soon as a permanent injury that generates lesions, it is difficult to treat by traditional treatment methods, which need to be solved in sports medicine. Transforming growth factor-β, an important factor regulating the formation of cartilage, stimulates or inhibits a variety of cells. By increasing the sensitivity of chondrocytes, transforming growth factor-βplays a central role in the process of repairing osteoarthritis cartilage injury, regulates in vitro protein synthesis, but also affect on the induction of specific granulation tissues. Bone morphogenetic protein-7 can induces cartilage-specific collagen and mucin production by mesenchymal and wound areas, which has promotive effect on cartilage reparation. CONCLUSION： Transforming growth factor-B or bone morphogenetic protein-7 has certain effect on knee cartilage injury; however, whether the combination of them can promote reparation of articular cartilage injury needs to be explored.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2009年第46期9151-9154,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
