药物结合物理疗法治疗宫颈HPV感染临床观察被引量：7

Effect of Combined Recombinant Human Interferon α 2A in Suppository Form and Microwave Therapy on Cervical Erosion with Human Papillomavirus Infection

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摘要目的:观察药物结合物理治疗宫颈糜烂合并HPV感染的临床疗效,并比较三种不同方法治疗宫颈糜烂合并HPV感染的临床疗效。方法:将150例宫颈糜烂合并HPV感染的患者随机分为三组,药物组50例,阴道放置奥平栓;微波组50例,经净后采用微波治疗;联合组50例,先行微波治疗,48小时后给予奥平栓阴道放置。观察各组治疗前后宫颈糜烂面与白带性状的变化,检测宫颈脱落细胞检测HPV感染情况。结果:三组治疗后白带量与性状改善均显著,差异无统计学意义(P>0.05)。对Ⅰ度和Ⅱ度宫颈糜烂疗效,三组有效率相近,差异无统计学意义(P>0.05);对Ⅲ度宫颈糜烂,联合组较奥平栓组及微波组疗效好,差异有统计学意义(P<0.05)。对单纯型糜烂,三组有效率均为100%;对颗粒型宫颈糜烂和乳突型宫颈糜烂,联合组疗效优于奥平栓组与微波组,差异有统计学意义(P<0.05);低危型HPV6/11的转阴率三组有效率差异无统计学意义(P>0.05);对高危型HPV16/18的转阴率,联合组疗效优于奥平栓组及微波组,差异有统计学意义(P<0.05)。结论:奥平栓联合微波治疗宫颈糜烂合并HPV感染疗效显著,副作用小,值得推广。 Objective：To observe the therapeutic efficiency of recombinant human interferon ct 2A in suppository form （ OPIN suppository） and microwave therapy for cervical erosion with human papillomavirus （HPV） infection. Methods： A total of 150 patients with cervical erosion with HPV infection were randomized into OPIN suppository group, microwave therapy group ,and combined microwave and OPIN group,50 patients in each. The microwave therapy was implemented 48 h before placing OPIN suppository in the combination group. Erosion area and leucorrhea eharacters were observed and HPV in cervcal exfoliated cells was detected before and after treatment. Results： The amount and characters of leucorrhea were improved in the 3 groups after treatment, with no significant difference among them （ P 〉 0.05 ）. For severe erosion, the combined microwave and OPIN group had better effect than other 2 groups did （ P 〈0. 05 ）. All treatments had effect on simple form of cervical erosion with a cure rate of 100% ; the combined microwave and OPIN group had better effect on granular and papillary forms than other 2 group did （ P 〈 0.05 ）. The negative rate of HPV 6/11 was not significantly different among the 3 groups（ P 〉 0.05 ） ; the negative rate of HPV 16/18 was much higher in the combined microwave and OPIN group than that in the other 2 groups （ P 〈 0.05 ）. Conclusion： Combined OPIN suppository and microwave has satisfactory effect on cervical erosion with HPV infeetion With less side effects.

作者赵小迎

机构地区温州医学院

出处《浙江中西医结合杂志》 2009年第12期737-739,共3页 Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

关键词宫颈糜烂 HPV 微波治疗奥平栓 cervical erosion human papillomavirus microwave therapy OPIN

分类号 R711.32 [医药卫生—妇产科学] R969.3 [医药卫生—药理学]

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参考文献7

1张银旺.360例宫颈疾病患者HPV亚型检测与分析[J].山东医药,2007,47(32):102-103. 被引量：10
2Chan PK, Mak KH, Cheung JL, et al. Genotype spectrum of cervical human pap illomavirus infection among sexually transmitted disease clinic patients in Hong Kong. J Med Virol,2002,68 (2) :273-277.
3MyersMccrory, Douglas, et al. Mathematical Model for the natural history of Human Papinomarirus Infection and Cervical Carcinogenesis. Am J Epidemiology,2000,151 (2) : 1158- 1171.
4杨英捷,赵健,李雪倩,廖秦平.人乳头状瘤病毒不同亚型感染与宫颈病变的相关性[J].中国妇产科临床杂志,2006,7(4):253-256. 被引量：54
5Jastreboff AM, Cymet T. Role of the human pap illoma virus in the development of cervical intraep ithelial neop lasia and malignancy. Postgrad Med J ,2002,78 (918) :225-228.
6Dalstein V, Riethmuller D, Pretet JL, et al. Persistent and load of high-risk HPV are predictors for development of high-grade cervical lesions: a longitudinal Freach cohort study. Int J Cancer,2003,106 (3) : 396-403.
7Suzanne M. Garland. Human papillomavirus update with a particular focus on cervical disease. Pathology,2002,34:213- 224.

二级参考文献11

1[1]Zur Hausen H.Papillomaviruses and cancer:from basic studies to clinical application.Nat Rev Cancer,2002,2:342-350.
2[2]Clifford GM,Smith JS,Plummer M,et al.Human papillomavirus types in invasive cervical cancer worldwide:a meta-analysis.Br J Cancer,2003,88:63-73.
3[3]Munoz N,Bosch FX,Sanjose S,et al.Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer.N Engl J Med,2003,348:518-527.
4[4]Chan PK,Mak KH,Cheung JL.etal.Genotype spectrum of cervical human papillomavirus infection among sexually transmitted disease clinic patients in Hong Kong.J Med Virol,2002,68:273-277.
5[5]Chan PK,Chang AR,Cheung JL,et al.Determinants d cervical human papillomavirus infection:differences between high-and low-oncogenic risk types.J Infect Dis,2002,185:28-35.
6[7]Woodman CB,Collins S,Winter H,et al.Natural history of cervical human papillomavirus infection in young women:a longitudinal cohort study.Lancet,2001,357:1831-1836.
7Dalstein V, Riethmuller D, Pretet JL, et al. Persistent and load of high-risk HPV are predictors for development of high-grade cervical lesions: a longitudinal Freach cohort study [J]. Int J Cancer, 2003, 106(3) :396-403.
8Chan PK, Mak KH , Cheung JL, et al. Genotype spectrum of cervical human papillomavirus infection among sexually transmitted disease clinic patients in Hong Kong [J]. J Med Virol, 2002,68(2) : 273 -277.
9Jastreboff AM, Cymet T. Role of the human papilloma virus in the development of cervical intraepithelial neoplasia and malignancy [J]. Postgrad Med J, 2002,78(918) :225-228.
10曹泽毅,赵健,廖秦平,郭秀婵,张永利,张拥军,曾毅.人乳头状瘤病毒与促癌物协同作用诱发人胚宫颈细胞恶性转化研究[J].中华医学杂志,2002,82(16):1108-1110. 被引量：6