期刊文献+

Ⅱ型胶原诱导的类风湿关节炎模型的制作 被引量:6

The establishment of-rheumatoid arthritis model induced by collagen Ⅱ
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摘要 Ⅱ型胶原诱导的类风湿关节炎模型CIA模型是目前最为理想的类风湿关节炎动物模型。受诸多因素影响,模型制作难度较大,成功率不高。结合参考国内外大量文献,本室多年研究经验,从动物品系的选择,胶原的配制和准备,注射的部位和方法,评价的指标等方面为CIA模型的制作提供了参考。 Rheumatoid Arthritis model induced by Collagen Ⅱ is the perfect animal model presently. Subject to many affective factors, this model is difficult to establish. This paper, with the references of literatures and the experience of our researches, reviews the selection of animals, collagen preparing, injection position and method, and the assessment of the animal model.
出处 《国际免疫学杂志》 CAS 北大核心 2009年第6期450-453,共4页 International Journal of Immunology
基金 国家自然科学基金资助项目(30873250)
关键词 Ⅱ型胶原 类风湿关节炎 模型 Collagen Ⅱ Rheumatoid Arthritis Model
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参考文献20

  • 1Robinson JH. Colony variability under the spotlight in animal models of arthritis. Arthritis Res Ther,2009,11 (2) :110-115.
  • 2Earp JC, Dubois DC, Molano DS, et al. Modeling Corticosteroid Effects in a Rat Model of Rheumatoid Arthritis I: Mechanistic Disease Progression Model for the Time Course of Collagen-Induced Arthritis in Lewis Rats. J Pharmacol Exp Ther, 2008,326 ( 2 ) : 532- 545.
  • 3Earp JC, Dubois DC, Molano DS, et al. Modeling corticosteroid effects in a rat model of rheumatoid arthritis Ⅱ : mechanistic pharmacodynamic model for dexamethasone effects in Lewis rats with collagen-induced arthritis. J Pharmcol Exp Ther, 2008,326 ( 2 ) : 546- 554.
  • 4Goodfellow RM, Williams AS, Levin L, el al. Soluble complement receptor one (sCRI) inhibits the development and progression of rat collagen-induced arthritis. J Clin Exp lmmuno1,2000,119( 1 ) :210- 216.
  • 5Zhang P,Han D, Tang T,et al. The destruction evaluation in diverent foot joints : new ideas in collagen-induced arthritis rat model. J Rheumatol,2009,29 ( 6 ) :607-613.
  • 6李宝丽,唐方,庞晓东.Ⅱ型胶原诱导关节炎大鼠模型制备[J].中国免疫学杂志,2006,22(4):350-352. 被引量:39
  • 7Zhou H, Wong YF, Wang J, et al. Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytoklnes in rats. J Biochem Biophys Res Commun ,2008,376 ( 2 ) : 352-357.
  • 8张锃锃,韩晓枫,金坚.鸡Ⅱ型胶原诱导的类风湿关节炎大鼠模型的建立[J].免疫学杂志,2006,22(5):552-554. 被引量:11
  • 9Khalifeh MS, Hananeh W,AI-Rukibat R, et al. Clinical and histopathological evaluation of MDP/collagen indutced arthritis rat model (MCIA) after treatment with Urtica dioica, plantago major and Hypericum pefforatum L herbal mixture. J Experimental Animals, 2008,57 (2) : 101-110.
  • 10Brahn E, Banquergo ML, Lee JK,et al. An Angiogenesis Inhibitor, 2-Methoxyestradiol, Involutes Rat Collagen-Induced Arthritis and Suppresses Gene Expression of Synovial Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor. J The Journal of Rheumatology ,2008,35 ( 11 ) :2119-2128.

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