摘要
Ⅱ型胶原诱导的类风湿关节炎模型CIA模型是目前最为理想的类风湿关节炎动物模型。受诸多因素影响,模型制作难度较大,成功率不高。结合参考国内外大量文献,本室多年研究经验,从动物品系的选择,胶原的配制和准备,注射的部位和方法,评价的指标等方面为CIA模型的制作提供了参考。
Rheumatoid Arthritis model induced by Collagen Ⅱ is the perfect animal model presently. Subject to many affective factors, this model is difficult to establish. This paper, with the references of literatures and the experience of our researches, reviews the selection of animals, collagen preparing, injection position and method, and the assessment of the animal model.
出处
《国际免疫学杂志》
CAS
北大核心
2009年第6期450-453,共4页
International Journal of Immunology
基金
国家自然科学基金资助项目(30873250)