摘要
以生物可降解材料聚乳酸-羟基乙酸(PLGA)为载体制备了载紫杉醇纳米粒,重点考察了纳米粒的体外释放特性。采用乳化-溶剂挥发法制备了载紫杉醇PLGA纳米粒,其平均粒径为200nm,载药量为21%,包封率为89.44%;体外释药符合Higuchi方程:Q=3.8796t^(1/2)+30.4649(r=0.9397),同时载紫杉醇纳米粒具有一定的缓释作用。
Paclitaxel loaded nanoparticles are prepared using biodegradable materials poly（lactic-co-glycolic acid） （PLGA） as drug carrier, with an emphasis on the release behavior study of the nanoparticles in vitro. Paclitaxel loaded PLGA nanoparticles are made by emulsion（O/W）-solvent evaporation process. The mean size, drug loading, encapsulation efficiency of paclitaxel loaded PLGA nanoparticles are 200nm, 21% ,89. 44% respectively. The in vitro release properties can be expressed by the Higuchi＇s equation Q=3. 8796t^1/2 ＋30. 4649（r=0. 9397） ,and paclitaxel loaded PLGA nanoparticles show sustained release.
