摘要
目的：探讨运动病的发生机理。方法：取ＳＤ大鼠１６只分为２组，其中１组按Ｃｒａｍｐｔｏｎ的方法进行旋转刺激诱导运动病；而非旋转组作为对照。用原位杂交和免疫组化方法、图像分析技术对旋转刺激组大鼠及对照组大鼠大脑、脑干和小脑中ｃ－ｆｏｓｍＲＮＡ、Ｆｏｓ蛋白含量变化进行定位、定量研究。结果：旋转刺激后３种组织中ｃ－ｆｏｓｍＲＮＡ、Ｆｏｓ蛋白的含量均有显著增加。
Abstract AIM: To study the motion sickness. METHODS:Sixteen rats (Sprague-Dowley, SD) were equally divided into two groups: the experimental group (MSG) with motion sickness induced by Cramptons mothod and the control group (CG) without motion sickness. A localization and quantitative study on changes of c-fos mRNA and Fos protein levels in cerebral cortex, brainstem and cerebellar cortex were carried out in rats of MSG and CG, by means of in situ hybridization, immunohistochemical analysis and image analysis. RESULTS: It was shown that the levels of c-fos mRNA and Fos protein in brain tissues of MSG were increased significantly after stimulation by rotation. CONCLUSION: The expression of c-fos gene in stress state involve in the process of motion sickness. MeSH Motion sickness; Genes,fos; Proto-oncogene proteins C-Fos; Brain
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1998年第6期755-757,共3页
Chinese Journal of Pathophysiology
