摘要
方法：本实验采用斑点免疫金银染色（Ｄｏｔ－ＩＧＳＳ）法对５０例ＳＬＥ患者血清中的肾小球基底膜抗体（ＧＢＭ－Ａｂ）及肾小管抗体（Ｔｕｂ－Ａｂ）进行检测。结果：ＧＢＭ－Ａｂ阳性率达６２％，Ｔｕｂ－Ａｂ阳性率达７６％。与患者尿蛋白检查（阳性率为４８％）比较，上述自身抗体检出率较高。此外，ＧＢＭ－Ａｂ或Ｔｕｂ－Ａｂ检测阳性患者与肾活检诊为狼疮性肾炎（ＬＮ）相符率达１００％。
Abstract METHODS:Antibody of glomerular basement membrane (GBM-Ab) and antibody of renal tubular antigen(Tub-Ab)in 50 patients with SLE were determined by dot-immunogold silver staining(Dot-IGSS) RESULTS:The positive rate of GBM-Ab was 62% and the positive rate of measuring the patient's proteinuria,was only 48%,the sensitivity of detecting GBM-Ab or Tub-Ab by Dot-IGSS was much higher.Moreover,the rate of coincident between GBM-Ab or Tub-Ab measuring and lupus nephritis(LN) diagnosis by renal biopsy was 100%.CONCLUSION:The detection of GBM-Ab or Tub-Ab would provide a reliable basis for LN diagnosis. MeSH Glomerular membranes;Antibodies;Lupus nephritis
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1998年第6期723-725,共3页
Chinese Journal of Pathophysiology
