摘要
目的：探讨小剂量醛氢叶酸（ＬＤＣＦ）、氟尿嘧啶（５Ｆｕ）与顺铂（ＰＤＤ）三药联用治疗晚期胃肠道癌的临床疗效。方法：３４例中胃癌１６例，结直肠癌１８例。ＣＦ３０ｍｇ／日，静滴２小时，５Ｆｕ１．０／日，于ＣＦ滴完后立即静滴，维持８～１２小时，连用５天；ＰＤＤ４０ｍｇ／日静滴，连用３天。结果：总有效率（ＣＲ＋ＰＲ）５２．９％，胃癌与结直肠癌的有效率分别为５６．３％、５０．０％。既往用过含５Ｆｕ方案的患者仍然有效（３８．９％）。主要毒副反应为静脉炎、口腔炎、食欲下降、恶心呕吐、骨髓抑制，多为Ⅰ～Ⅱ级，大部分病人能耐受。结论：作者认为该方案毒性较低、疗效好。
Objective: To study the immediate response of advanced gastrointestinal cancer treated with low dose of leucovorin (LDCF)、 5 Fu and PDD. Methods: Low dose of leucovorin (LDCF)、5 Fu and PDD therapy were used in 34 histologically proven advanced gastrointestinal cancer patients, among which 16 cases were gastric cancer, 18 were colonic cancer. LDCF 30 mg/day iv in 2h; 5 Fu 1.0/day iv was given during 8～12h immediately when LDCF was over. They were repeated for 5 days, while PDD 40 mg/day was given iv through another venous for 3 days. Results: Total effective rate (CR+PR) was 52.9%. The effective rate for gastric and colonic cancers were 56.3% and 50.0%. Those who had been treated with 5 Fu previously were still effective (38.9%). Among side effects, phlebitis was most common seen. The other symptoms were gastrointestinal reaction and leukemia. Most were grade Ⅰ～Ⅱ which were tolerable for the patients. Conclusion: Uses of LDCF、5 Fu and PDD in advanced gastrointestinal cancers is worthwhile of further study.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1998年第6期462-464,共3页
Chinese Journal of Cancer
关键词
胃肠肿瘤
药物疗法
醛氢叶酸
氟尿嘧啶
顺铂
Gastrointestinal neoplasms/drug therapy
Fluorouracil/therapeutic use
Cisplatin/therapeutic use
