期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

阿司匹林抵抗研究进展 被引量：19

Research Advances in Aspirin Resistance
暂未订购
导出
摘要 阿司匹林是抗血栓治疗的重要药物,阿司匹林抵抗是影响其疗效的常见原因。阿司匹林抵抗目前主要指实验室阿司匹林抵抗,可通过血栓素A2测定,依赖血栓素的血小板功能试验来诊断。多项临床试验证实,实验室阿司匹林抵抗和临床血管事件相关。 Aspirin is an important antithrombotic agent. However, its clinical benefit is impaired by aspirin resistance. The term of ＂aspirin resistance＂ usually refers to laboratory resistance. It can be identified by measuring thromboxane A2 or thromboxane-dependent platelet function. Clinical trials have shown that laboratory aspirin resistance is correlated with vascular events.
作者 斯晓燕 赵永强
机构地区 中国医学科学院北京协和医学院北京协和医院血液内科
出处 《中国医学科学院学报》 CAS CSCD 北大核心 2009年第5期644-650,共7页 Acta Academiae Medicinae Sinicae
关键词 阿司匹林 阿司匹林抵抗 aspirin aspirin resistance
分类号 R973 [医药卫生—药品]
  • 相关文献

参考文献39

  • 1Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy-I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration [ J ]. BMJ, 1994, 308 (6921) :81- 106.
  • 2Antiplatelet Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients [J]. BMJ, 2002, 324(7329) :71-86.
  • 3Bhatt D, Topoi EJ. Scientific and therapeutic advances in antiplatelet therapy [ J]. Nature Rev, 2003, 2( 1 ) : 15-28.
  • 4Cattaneo M. Resistance to antiplatelet drugs: molecular mechanisms and laboratory detection [ J]. J Thromb Haemost, 2007, 5( Suppl 1 ):230-237.
  • 5Rand ML, Leung R, Packham MA. Platelet function assay [ J]. Transfus Apheresis Sci, 2003, 28 (3) :307-317.
  • 6Harrison P. Progress in the assessment of platelet function [J]. Br J Heamatol, 2000, 111(3):733-744.
  • 7Michelson AD. Platelet function testing in cardiovascular diseases [J]. Circulation, 2004, 110(19) :e489-e493.
  • 8Kawasaki T, Ozeki Y, Igawa T, et al. Increased platelet sensitivity to collagen in individuals resistant to low-dose aspirin [J]. Stroke, 2000, 31(3):591-595.
  • 9Gum PA, Kottke-Marchant K, Poggio ED, et al. Profile and prevalence of aspirin resistance in patients with cardiovascular disease [J]. Am J Cardiol, 2001, 88(3) :230-235.
  • 10Eikelboom JW, Hirsh J, Weitz JI, et al. Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events [ J ] . Circulation, 2002, 105 (14) :1650-1655.

二级参考文献19

  • 1Cipollone F,Patrignani P,Greco A,et al.Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina[J].Circulation,1997,96(4):1109-1116.
  • 2Cipollone F,Prontera C,Pini B,et al.Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis prostaglandin E (2)-dependent plaque instability[ J ].Circulation,2001,104(8):921-927.
  • 3Weber AA,Zimmermann KC,Meyer-Kirchrath J,et al.Cyclooxygenase-2 in human platelets as a possible factor in aspirin resistance[J].Lancet,1999,353 (9156):900.
  • 4Karim S,Habib A,Levy-Toledano S,et al.Cyclooxygenase-1 and-2 of endothelial cells utilize exogenous or endogenous arachidonic acid for transcellular production of thromboxane[J].J Biol Chem,1996,271(20):12042-12048.
  • 5Macchi L,Christiaens L,Brabant S,et al.Resistance to aspirin in vitro is associated with increased platelet sensitivity to adenosine diphosphate[J].Thromb RES,2002,107 (1-2):45-49.
  • 6Kawasaki T,Ozeki Y,Igawa T,et al.Increased platelet sensitivity to collagen in individuals resistant to low-dose aspirin[J].Stroke,2000,31(3):591-595.
  • 7Bojesen SE,Juul K,Schnohr P,et al.Platelet polymorphism of glycoprotein Ⅲa and risk of adverse events after coronary srent placement[J].J Am Coll Cardiol,2003,42(4)661-667.
  • 8Ridker PM,Manson JE,Buring JE,et al.Clinical characteristics of nonfatal myocarid infaction among individuals on prophylactic low-dose aspirin therapy[J].Circulation,1991,84(2):708-711.
  • 9Mueller MR,Salat A,Stangl P,et al.Variable platelet response to low-dose ASA and the risk of limb deterioration in patients submitted to peripheral arterial angioplasty[J].Thromb Haemost,1997,78(3):1003-1007.
  • 10Buchanan MR,Brister SJ.Individual variation in the effects of ASA on platelet function:implications for the use of ASA clinically[J].Can J Cardiol,1995,11 (3):221-227.

共引文献1

同被引文献190

引证文献19

二级引证文献112

中国医学科学院学报
2009年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部