摘要
目的:探讨乙肝患者血清中乙肝病毒血清标志物、乙肝病毒核酸含量与血清肝纤维化检测的关联。方法:对203例乙肝患者应用酶联免疫吸附法(ELISA)检测乙肝血清标志物,荧光定量聚合酶链反应法(FQ-PCR)检测血清中乙肝病毒核酸含量,肝纤维化血清化学发光检测法测定乙肝患者透明质酸酶(HA)、层黏蛋白(LN)、Ⅲ型胶原前肽(PCⅢ)、Ⅳ型胶原(Ⅳ-C)在血清中的含量。结果:乙肝病毒血清标志物、乙肝病毒核酸含量与血清肝纤维化检测值的缓慢升高有关联(P<0.01),但不呈直线关系。结论:血清肝纤维化检测可推测乙肝病毒对肝脏慢性持续性损伤和肝纤维化进程,但不能用于肝炎重度和肝硬化的鉴别判断。
Objective：Studies serum markers of HBV,HBV nucleic content with detection of the value serum liver fibrosis.Methods：To studies 203 cases sufferer app enzyme-linked immunosorbent assay checked up HBV serum markers,fluoressence quantitative polymerase chain reaction checked up serum HBV nucleic acid content;Liver fibrosis serum chemiluminescence checked up hepatitis B hyaluronidase、laminin、type Ⅲ procollagen peptide、collagen Ⅳlevels of in serum.Results：Serum markers of HBV、HBV nucleic content with detection of the value of serum liver the value of the siow increased have associate but non-linear relationship between.Conclusions：Serum hepatic fibrosis checked can conjectured the course HBV with chronic persistent liver injury and liver fibrosis.But can not be used for estimate and inentification severe hepatitis and cirrbosis.
出处
《中国医药导刊》
2009年第11期1909-1909,1911,共2页
Chinese Journal of Medicinal Guide
