摘要
目的:探讨中医药治疗脑出血最佳疗效出血量的界定。方法:72只wistar大鼠随机分为3组,假手术组、模型组和治疗组,模型组和治疗组又各分为4个小组,每组8只大鼠。造模后,假手术组和模型组给予安慰剂,治疗组给予中药治疗。给药3天后腹主动脉取血采用夹心酶联免疫法测定血清NSE浓度。结果:中药治疗组血清NSE水平明显低于模型组(P<0.05),特别是小量出血组(27μL、40μL)NSE水平明显低于大量出血组(53μL、67μL)(P<0.05)。结论:①中药对脑出血后血清NSE水平的调控有明显效果,可以保护脑组织的损伤,对小量脑出血作用更加明显。②NSE是反映脑出血后脑损伤程度的敏感指标。③提示NSE是否存在一个在机体发生实质性损伤时的临界点。
Objective ：Traditional Chinese Medicine to explore the treatment of cerebral hemorrhage the best effect of defining the amount of bleeding. Methods ： 72 wistar rats were randomly divided into 3 groups, Sham group, model group and treatment group,Model group and treatment group was divided into four groups,each group of 8 rats. the sham group and model group,will treat by the placebo, the treatment group will treat by traditional Chinese medicine. 3 days after the delivery of abdominal aortic blood. ELISA method using serum concentrations of NSE. Results：The treatment group serum NSE lower than the model group,In particular the small amount of bleeding group （27 uL and 40 uL） （P 〈 0. 01 ）. Conclusion：（1）Chinese medicine for cerebral hemorrhage after the serum NSE level of control there are obvious effects, can protect brain damage, a small amount of cerebral hemorrhage more pronounced effect. （2）NSE is a reflection of cerebral hemorrhage of the brain damage sensitive targets. （3）NSE prompted the existence of a substantial body damage when the critical point.
出处
《辽宁中医杂志》
CAS
北大核心
2009年第11期1987-1988,共2页
Liaoning Journal of Traditional Chinese Medicine
基金
教育部高等学校博士点科研基金课题(20060199002)
关键词
中医药
脑出血
NSE
最佳出血量
Chinese medicine
Cerebral Hemorrhage
NSE
Best amount of bleeding
