摘要
目的探讨乳腺癌腔镜腋窝淋巴结清扫术安全性。方法 64例乳腺癌患者分为腔镜手术组和传统手术组,每组32例。应用荧光实时定量PCR技术分别检测乳腺癌患者术前和术后外周血CK-19 mRNA表达。结果 64例乳腺癌患者外周血CK-19 mRNA阳性率32.81%,腔镜手术组和传统手术组的外周血CK-19 mRNA阳性率分别为31.25%和34.38%,两组手术可能造成的外周血潜伏肿瘤细胞(OTC)扩散几率分别为4.34%和8.70%,两组比较无显著差异。术前化疗后乳腺癌患者外周血中仍然存在OTC,且随肿瘤分期的增高而增多。结论腔镜腋窝淋巴结清扫手术对外周血潜伏肿瘤细胞的影响与传统手术相比无显著性差异,腔镜腋窝淋巴结清扫手术与传统腋窝淋结清扫术相比不增加肿瘤扩散的风险。
Objective To evaluate the safety of endoscopic axillary lymph node dissection （E-ALND） by liposuction. Methods Sixty-four cases of breast cancer were divided into an E-ALND group and a traditional ALND group, 32 cases in each group. CK-19 mRNA copy numbers in peripheral blood were detected with SYBR Green I real time polymerase chain reaction before and after operation. Results The positive expression rate of CK-19 mRNA was 32.81% in peripheral blood in the 64 patients, and 31.25% and 34.38% in the E-ALND group and the ALND group, respectively. The likelihood of hemotogenous dissemination of tumor cells was 4.34% and 8.70% in the E-ALND group and the ALND group, respectively;OTC （ occult tumor cell） in peripheral blood of patients who underwent preoperative chemotherapy could still be detected, and increased with the upgrading of breast cancer stage. Conclusions There is no difference in hemotogenous dissemination of tumor cells in breast cancer between E-ALND and traditional ALND. Compared with the ALND group, the likelihood of hemotogenous dissemination of tumor cells does not increase in the E-ALND group.
出处
《中华乳腺病杂志（电子版）》
CAS
2007年第3期36-39,共4页
Chinese Journal of Breast Disease(Electronic Edition)
