摘要
目的：探讨血浆P－选择素和IL－8的测定在急性呼吸窘迫综合征（ARDS）中的临床价值。方法：分别采用放免法和酶联免疫吸附法检测25例ARDS患者血浆P－选择素和IL－8，同时行APACHEⅡ评分。结果：ARDS患者血浆P－选择素和IL－8明显高于正常对照组（P＜0．01），且随着APACHEⅡ评分增高，P－选择素也明显增高，两者呈正相关（P＜0．01）；死亡患者血浆P－选择素、IL－8及APACHEⅡ评分均显著高于存活患者（P＜0．05）；综合治疗后，存活患者P-选择素和LT－8下降（P＜0．05）。结论：P－选择素和IL－8可能参与了ARDS的发病，测定血循环P－选择素和IL－8的水平，并结合APACHEⅡ评分可作为判断ARDS病情严重程度的参考指标。
Aim: To investigate the clinical significance of plasma P-selectin and interleukin-8 (IL-8)in patients with acute respiratory distress syndrome (ARDS). Methods: P-selectin and IL-8 leveIs were deter mined by ELISA and RAST in 25 patients with ARDS. APACHE Ⅱ was also evaluated. Results: P-selectin and IL-8 levels were significantly higher in patients with ARDS than those in normal controls. P-selectin levels were elevated following the increasement of APACHE Ⅱ. A positive correlation was noticed between APACHE Ⅱ and P-selectin (P< 0.01 ). A marked difference was observed among P-selectin, IL-8 and APACHE Ⅱin surviors compared to nonsurviors (P< 0.05). After systemic therapy, P-selectin and IL-8 levels were de creased (P <0.05). Conclusion: P-selectin and IL-8 may be involved in the pathogenesis of ARDS. Mea surement of plasma P-selectin and IL-8, combined with APACHE Ⅱ, might be taken as a useful marker to judge the severity in patients with ARDS.
出处
《急诊医学》
CSCD
1998年第6期384-386,共3页
