摘要
目的探讨原发性干燥综合征抗SSA抗体、抗SSB抗体与血液系统损害之间有无相关关系。方法分析84例PSS患者抗核抗体、抗SSA、抗SB抗体以及血常规检测结果。结果60例抗SSA抗体阳性者中出现血液系统损害43例(71.7%),白细胞减少28例(46.7%),贫血26例(43.3%),24例抗SSA抗体阴性者中出现血液系统损害10例(41.7%),白细胞减少4例(16.7%),贫血4例(16.7%),组间比较,均有显著性差异(P<0.05)。结论抗SSA抗体可能与PSS的血液系统损害,特别是白细胞减少、贫血密切相关,对PSS病情及预后评价有一定的意义。
Objective To investigate the relationship between Hematologic abnormalities such as leukopenia,anemia and thrombocytopenia and immunologic markers such as Anti-Ro （SS-A） and anti-La （SS-B） antibodies in primary Sjogren＇S syndrome（PSS）. Methods The results of immunologic markers such as ANA, Anti-Ro （SS-A） and anti-La （SS-B） antibodies and complete blood count in 84 patients with PSS were analyzed. Results The incidence of hematologic involvement in patients with positive assays of Anti-Ro （SS-A） antibodies was significantly higher than that with negative assays（71.7% VS 41.7% ,P〈0.05）. The incidence of leukopenia in patients with positive assays of Anti-Ro （SS-A） antibodies was significantly higher than that with negative assays（46.7% VS 16.7% ,P,（0.05）. The incidence of anemia in patients with positiveassays of Anti-Ro （SS-A） antibodies was significantly higher than that with negative assays（43.3 VS 16.7%,P〈0.05）. Conclusion Anti-Ro （SS-A） antibodies may be closely associated with the Hematologic involvement,especially leukopenia and anemia, which could be helpful in estimating the pathogenetic condition and prognosis in PSS.
出处
《西部医学》
2009年第11期1943-1944,共2页
Medical Journal of West China
