摘要
目的观察复方苦参注射液联合化疗治疗非小细胞肺癌的疗效及毒副反应。方法 144例非小细胞肺癌患者随机分成复方苦参注射液联合化疗的治疗组76例,单纯化疗的对照组68例,经2个周期治疗后比较两组的近期疗效,止痛效果及毒副反应。结果治疗组近期疗效有效率为39.47%(30/76)高于对照组35.29%(24/68),两组无差异性(P>0.05)。治疗组止痛缓解率、总有效率分别为69.70%(23/33)、93.94%(31/33)均高于对照组68.75%(22/32)、90.63%(29/32),两组无差异性(P>0.05)。毒副反应主要为骨髓抑制,以白细胞减少最明显,治疗组发生率78.95%低于对照组(82.35%),其中治疗组Ⅲ、Ⅳ度白细胞减少发生率明显低于对照组,但两组均无差异性(P>0.05)。两组血红蛋白、血小板减少、胃肠道反应及心肝肾功能异常等发生率均相近,均无差异性。结论复方苦参注射液联合化疗治疗非小细胞肺癌可以提高疗效,减轻毒副反应。
Objective To evaluate the effect of Kushen injection and chemotherapy in non - small cell lung cancer patients. Methods 144 cases of non - small cell lung cancer patients were randomly divided into two groups ：76 cases were treated with Kushen injection and chemotherapy, while 68 cases were treated with routine chemotherapy. The therapy in both groups lasted two cycles. Results The effect in treatment group was superior to that in control group. The efficiency rates in two groups were 39.47 % and 35.29% （ P 〉 0.05 ）. The decline of white blood cell was main side effect, the incidence rates in two groups were 78.95% and 82. 35% ,but the rate in treatment groups of WBC decline in Ⅲ, Ⅳ degree（ 15.79% and 2. 63% respectively） was lower apparently than that in control group（20.59% and 5.88% respectively） （P 〉0.05 ）. Conclusion The application of Kushen injection and chemotherapy in non - small cell lung cancer patients can improve effect, and decrease the incidence rates of side effect of chemotherapy.
出处
《中国医学创新》
CAS
2009年第32期14-16,共3页
Medical Innovation of China
