摘要
目的比较米非司酮配伍米索前列醇、利凡诺配伍米非司酮及单纯使用利凡诺在中期引产中的效果。方法235例12—28周要求终止妊娠孕妇，随机分成3组：观察1组、观察2组和观察3组。观察1组80例，米非司酮50nag空腹或饭后2h口服，12h1次，连用3d，第4天米索前列醇阴道上药，剂量200～1000μg；观察2组78例，利凡诺羊膜腔注射，剂量70～100mg，同时米非司酮75nag空腹或饭后2h口服，12h 1次。共1d；观察3组77例，仅用利凡诺羊膜腔注射，剂量70-100mg。结果观察1组、观察2组和观察3组完全流产率分别为88．75％（71／80）、65．38％（51／78）、38．96％（30／77），成功率分别为98．75％（79／80）、71．79％（56／78）、76．62％（59／77）。开始宫缩至胎儿胎盘娩出时间分别为（6．85±3．68）、（8．87±3．58）、（14．67±3．50）h，产时至产后2h阴道出血量分别为（80．86±40．28）、（94．70±42．35）、（120．68±43．30）ml。观察1组完全流产率、成功率高于观察2组和观察3组，而且产程短、出血少，差异有统计学意义（P均〈0．01）。观察2组完全流产率高于观察3组，且产程缩短，差异有统计学意义（P〈0．01）。结论米非司酮配伍米索前列醇引产具有完全流产率高、成功率高、产程短、出血少等优，点，特别适用于孕20周以下中期引产；利凡诺配伍米非司酮引产能够提高完全流产率，缩短产程，减少出血，适合于孕周16周以上引产：单纯利凡诺引产产程长。疼痛较重，不全流产率较高。
Objective To compare the effects of three artificial abortion methods, Mifepriston with Misoprofil,Rivanol with Mifepristone and Rivanol,in mid-term pregnancy. Methods 235 women who were pregnant for 12 to 28 weeks and volunteered to abort with drugs were selected and observed. The total subjects were randomly divided into three groups,study group Ⅰ （n = 80） ,study group Ⅱ （n =78） ,and control group （n =77）. In study group Ⅰ , each was given Mifepristone 50 mg,po,bid,for 3 days. On the fourth day,Misoprofil 200-1000 p,g was administered though vagina. In study group Ⅱ, Rivanol（70-100 mg） was injected into amniotic cavity and at the same tame, Mifepristone,75 mg was given bid,po,for each case for 1 day. In study group Ⅲ ,each case was injected with Rivanol （70-100 mg） only into amniotic cavity. Results The complete abortion rate in study group Ⅰ , Ⅱ and Ⅲ was 88.75% （71/80）,65.38% （51/78）,38.96% （30/77） respectively. The success rate was 98.75% （79/80）, 71.79% （56/78）, 76.62% （59/77） respectively. The mean time from the initial uterine contraction to the expulsion of the fetus and placenta was （6.85 ± 3.68 ） h, （8.87 ± 3.58 ） h, （ 14.67 ± 3.50） h respectively. The volume of intrapartum and postpartum vaginal hemorrhage within 2 hours was （ 80.86 ± 40.28 ） ml, （94.70 ± 42.35 ） ml, （ 120. 68 ± 43.30） ml respectively. The complete abortion rate and success rate in study group Ⅰ was significantly greater than that in study group Ⅱ and study group Ⅲ. In addition,the birth process was shorter and the vaginal hemorrhage was less significantly in study group Ⅰ than those in the other two groups （ P 〈 0.01 ）. The complete abortion rate in study group Ⅱ was significantly greater than that in study group Ⅲ （ P 〈 0.01 ）. Conclusions Mifepristone administered with Misoprpfil has many advantages usages, such as high complete abortion rate and success rate, short birth process, and less volume of vaginal hemorrhage, when used for artificial abortion in mid-term pregnancy. They are especially suitable for the mid-term artificial abortion under 20-week pregnancy. Rivanol administered with Mifepristone can raise complete abortion rate, shorten labor process and decrease vaginal hemorrhage when they are used in artificial abortion. They are suitable for the mid-term artificial abortion above 16-week pregnancy. The stage of labor lasts long when using only Rivanol for artificial abortion. The pain is relatively heavier and the rate of incomplete abortion is higher.
出处
《中国综合临床》
2009年第11期1221-1223,共3页
Clinical Medicine of China
