摘要
脓毒症是一组与严重感染相关的综合征。正常的宿主对于感染的反应比较复杂,其能够识别和控制侵袭性病原体,并迅速地开始组织修复。此时机体的细胞免疫和体液免疫都被激活,导致发生抗炎和促炎性反应。如果这些机制没有得到很好的控制,导致恶化,则会出现一系列的变化而导致脓毒症的发生,并促进大量的介质释放,进而发展为多器官功能障碍。目前,尽管对于脓毒症的病理生理途径和进程有了很多的认识,但其发病率和病死率仍然很高。
Sepsis is a syndrome related to severe infections. The immune response to infection is complex, the activation of this process is to identify and control pathogen invasion, as well as to start immediate tissue repair. Meanwhile, both the cellular and humoral immune systems are activated, giving raise to both anti-inflammatory and proinflammatory responses. The chain of events that leads to sepsis is derived from the exacerbation of these mechanisms, promoting massive liberation of mediators and the progression of multiple organ dysfunctions. Despite increasing knowledge about the pathophysiological pathways and processes involved in sepsis, morbidity and mortality remain unacceptably high.
出处
《医学综述》
2009年第21期3230-3232,共3页
Medical Recapitulate
