摘要
目的探讨中国汉族人群中5-羟色胺转运体基因启动子区域多态（5-HTTLPR）功能性3等位基因LA、LG和S与强迫症（OCD）的关系。方法采用聚合酶链反应-限制性片段长度多态技术测定138例OCD患者（OCD组）和199名健康人（对照组）的5-HTYLPR功能性3等位基因多态性。结果OCD组5-HTTLPR功能性基因型及等位基因频率与对照组间的差异有统计学意义（x^2=8．396，P〈0．05；x^2=8．483，P〈0．01）；LA／LA基因型和LA等位基因与OCD存在显著正关联[比值比分别为3．361（P〈0．05）和1．771（P〈0．01）]。结论在中国汉族人群中5-HTTLPR功能性3等位基因可能与OCD存在遗传关联，LA／LA基因型和等位基因LA可能是OCD的风险因子。
Objective To explore the association between functionally triallelic polymorphism, alleles LA, LG and S of serotonin transporter gene linked polymorphism （5-HTTLPR） and obsessivecompulsive disorder（OCD） in Chinese Han nationality. Methods Altogether 138 OCD patients and 199 healthy controls were included in this study. The subjects were genotyped directly with polymerase chain reaction and restriction fragment length polymorphism techniques. Results There were significant differences between patients and controls on genotype and allele frequencies of functionally polymorphism of 5-HTrPLR （ x^2 = 8. 396,P 〈 0. 05 ; x^2 = 8. 483, P 〈 0. 01 ）. The LA/LA genotype and allele LA were positively associated with OCD（ OR = 3. 361 and 1. 771, P 〈 0. 05 ）. Conclusions The results suggest that the functionally polymorphism of 5-HTTLPR may be associated with OCD in Chinese Han nationality, and LA/LA genotype and LA allele may be the risk factors of OCD.
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2009年第4期215-219,共5页
Chinese Journal of Psychiatry
基金
国家高技术研究发展计划资助项目（863计划）（2007AA022420）
上海市市级医院新兴前沿技术联合攻关资助项目（SHDC12006105）
上海市科委重点科技攻关资助项目（074119520）
上海市优秀学科带头人计划资助项目（08XD14036）
关键词
强迫性障碍
血清素质膜转运蛋白质类
基因
多态性
限制性片段长度
Obsessive-compulsive disorder
Serotonin plasma membrane transport proteins
Gene
Polymorphism, restriction fragment length
