期刊文献+

谷氨酸系统在强迫症发病机制中的作用 被引量:6

原文传递
导出
摘要 强迫症是一种以无法控制的强迫思维和(或)强迫行为为临床特征的精神疾病,其突出特点是自我强迫与反强迫同时存在,两者强烈的冲突使患者感到焦虑和痛苦,严重影响患者日常生活和社会功能。强迫症终生患病率为1%~3%。虽然在100年前,强迫症就作为一种精神疾病被人们所认识,但到目前为止,强迫症的病因仍然未明,其治疗仍然是一个非常困难的问题,世界卫生组织提供的数据表明,强迫症是全球最严重的十大致残性疾病之一。
出处 《中华精神科杂志》 CAS CSCD 北大核心 2013年第5期314-317,共4页 Chinese Journal of Psychiatry
基金 国家自然科学基金(81171280) 国家“863”计划高技术研究发展计划(2007AA022420) 上海市市级医院新兴前沿技术联合攻关项目(SHDC12006105) 上海交通大学医学院“博士创新基金项目”(BXJ201047) 上海市优秀学科带头人计划(08XD14036)
  • 相关文献

参考文献37

  • 1Ruscio AM, Stein DJ, Chiu WT, et al. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry,2010,15:53-63.
  • 2Nestadt G, Grados M, Samuels JF. Genetics of obsessive- compulsive disorder. Psychiatr Clin North Am,2010,33 : 141-158.
  • 3王雪梅,肖泽萍.强迫症治疗方法及进展[J].中华行为医学与脑科学杂志,2009,18(11):1054-1056. 被引量:17
  • 4Chakrabarty K, Bhattacharyya S, Christopher R, et al. Glutamatergic dysfunction in OCD. Neuropsychopharmacology, 2005,30 : 1735-1740.
  • 5Pittenger C, Bloch M, Wegner R, et al. Glutamatergic dysftmction in obsessive-compulsive disorder and the potential clinical utility of glutamate-modulating agents. Primary Psychiatry, 2006, 13:65-77.
  • 6Grant P, Song JY, Swedo SE. Review of the use of the glutamate antagonist riluzole in psychiatric disorders and a description of recertt use in childhood obsessive-compulsive disorder. J Child Adolesc Psychopharmacol, 2010,20:309-315.
  • 7RotgeJY, Aouizerate B, Tignol J, et al. The glutamate-based genetic immune hypothesis in obsessive-cmnpulsive disorder. Anintegrative approach from genes to symptoms. Neuroscience,2010, 165:4084-17.
  • 8Menzies L, Chamberlain SR, Laird AR,et al. Integrating evidence from neuroimaging and neuropsychological studies of obsessive- compulsive disorder: the orbitofronto-striatal model revisited. Neurosci Biobehav Rev ,2008,32:525-549.
  • 9Rosenberg DR, MacMaster FP, Keshavan MS,et al. Decrease in eaudate glutamatergie concentrations in pediatric obsessive- compulsive disorder patients taking paroxetine. J Am Acad Child Adolesc Psychiatry,2000,39 : 1096-1103.
  • 10Bohon J, Moore GJ, MacMillan S, et al. Case study: caudate glutamatergic changes with paroxetine persist after medication discontinuation in pediatric OCD. J Am Acad Child Adolesc Psychiatry ,2001,40:903-906.

二级参考文献45

  • 1张海音,王祖承,孙伯民.双侧内囊前肢毁损术治疗难治性强迫症疗效及随访研究[J].上海精神医学,2004,16(3):149-152. 被引量:13
  • 2肖泽萍,张明岛,严和骎.强迫症的生化、内分泌研究进展[J].上海精神医学,2002,14(2):109-110. 被引量:5
  • 3蔡厚德.强迫症的脑功能障碍[J].心理科学进展,2006,14(3):401-407. 被引量:12
  • 4张玉,范习祥.精神分裂症强迫症状研究现状[J].临床心身疾病杂志,2007,13(2):192-192. 被引量:4
  • 5Weissman MM,Bland RC,Canino GJ,et al.The cross national epidemiology of obsessive compulsive disorder.The Cross National Collaborative Group.J Clin Psychiatry,1994,55:5-10.
  • 6Koran LM,Thienemann ML,Davenport R.Quality of life for patients with obsessive-compulsive disorder.Am J Psychiatry,1996,153:783-788.
  • 7van Grootheest DS,Cath DC,Beekman AT,et al.Twin studies on obsessive-compulsive disorder:a review.Twin Res Hum Genet,2005,8:450-458.
  • 8Rotge JY,Guehl D,Dilharreguy B,et al.Meta-analysis of brain volume changes in obsessive-compulsive disorder.Biol Psychiatry,2009,65:75-83.
  • 9Ursu S,Carter CS.An initial investigation of the orbitofiontal cortex hyperactivity in obsessive-compulsive disorder:exaggerated representations of anticipated aversive events? Neuropaychologia,2009,47:2145-2148.
  • 10Whiteside SP,Port JD,Abramowitz JS.A meta-analysis of functional neuroimaging in obsessive-compulsive disorder.Psychiatry Res,2004,132:69-79.

共引文献41

同被引文献38

引证文献6

二级引证文献26

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部