摘要
报道了两种制备[99mTc≡N]中间体的方法。在N的供体及还原剂（TPPS，SnCl2）存在的条件下制备[99mTc≡N]中间体，两种方法制得的中间体的组成不同，但均为混合物，而且与配体反应，都可以制得以[99mTc≡N]2+为中心核的配合物。用HPLC检测标记中间体在不同pH时的组成变化及稳定性情况。
Two methods for the synthesis of the [99mTc≡N] intermediates were reported. In the presence of reducer (TPPS or SnCl2) and the donor of N, the mixture of [99mTc≡N] intermediate could be conveniently synthesized but with different composition. On reaction with ligands complexes containing [99mTc≡N]2+ core can be obtained. The change of composition of Intermediates was detected by HPLC at different PH values,and the stability was also evaluated.
出处
《核技术》
CAS
CSCD
北大核心
1998年第11期656-658,共3页
Nuclear Techniques
基金
江苏省自然科学基金!BK95120313
卫生部优秀青年人才专项科研基金!96Q-077
江苏省卫生厅科研课题基金!H9534资助
关键词
同位素标记
中间体
锝99M
制备
Isotope labelling, [99m^Tc≡N] intermediate, NOEt
