摘要
目的:评价99mTc-N(NOEt)2在小鼠肝脏肿瘤模型显像中的应用价值。方法:昆明种小白鼠21只,随机选择12只行99mTc-N(NOEt)2体内分布试验,采用百分注射剂量率(%ID)评定。另外9只用作肿瘤实验鼠,每只种植H22肝癌模型小鼠腹水0.1ml制备动物模型,肿瘤直径大于2cm后开始实验,采用SPECT显像技术评定Tc-N(NOEt)2在肿瘤显像中的作用,记录T/N作为评定指标,并与99mTc-MIBI在相同条件下进行比较。结果:99mTc-N(NOEt)2在肝脏、肺、肾、心脏分布较多。在肺中代谢快,心/肺比值随时间延长而增大,120min时达最大值。肝脏、肾脏于90min时摄取率最高,然后开始下降。99mTc-N(NOEt)2组T/N120min时最高,此时肝脏的摄取已开始下降,显像的最佳时间为120min。在注射后30min和90min时99mTc-N(NOEt)2与99mTc-MIBI的T/N差异无显著性意义,在120min时99mTc-N(NOEt)2摄取明显高于99mTc-MIBI。结论:99mTc-N(NOEt)2在小鼠体内分布快;以心脏摄取较快,摄取率较高,排泄慢,因此此药物适合心肌显像,但其在肺中的摄取高,有可能干扰心肌显像。99mTc-N(NOEt)2在小鼠肝癌显像中有肯定意义,在120min时肿瘤显像最佳,99mTc-N(NOEt)2有可能成为一种新型的肝脏肿瘤显像剂。
Objective： To study the bio distribution of ^99mTc-N（NOEt）2 and evaluate the clinical value of ^99mTc- N（NOEt）2, in liver carcinoma imaging,and to compare with ^99m, Tc-MIBI in similar conditions. Methods： 21 K unming mice were selected, 12 of them were chosen randomly for the study of bio-distribution of ^99mTc- N（NOEt）2. The result was assessed by %ID （percent of injection dose per gram） ,the other mice were used for building up mice model with liver tumor by injection of 0. lml ascites from H22 liver carcinoma mice. After the diameter of implanted tumor reached 2.0cm,experiment was begun by using the technology of SPECT.ROI was taken to evaluate the role of ^99mTc-（NOEt）2 in tumor imaging,with T/N as index of evaluation. Results： Uptake of ^99m＇Tc-N（NOEt）2, was more concentrated in liver,lung,kidney and heart. Metabolism was obviously fast in lung. The uptake ratio of heart/lung increased with time and reached to maximum at 120min. The peak value of uptake of liver.kidney was at 90min and declined slowly. The peak value of T/N in the group of ^99mTc-N（NOEt）2 was at the time of 120min. AT the same time the uptake of liver started to decline,therefore,the best timing for imaging is at or after 120min. There was no significant difference when comparison of ^99mTc- N（N（OEt）2 with ^99mTc- MIBI at 30min, 90min were done,but the uptake was much higher in the group of ^99mTc-N（NOEt）2 than that of ^99mTc-MIBI at 120min and significant difference was existed. Conclusion ： Rapid bio distribution of ^99mTc-N（NOEt） 2 could be revealed in mice, especially in myocardium,with rapid and high uptake and slow excretion,it is suitable to be one of the new myocardium imaging agent. The vdue of %Ⅱ） was high in lung and liver throughout the whole process and the myocardium imaging might be disturbed.^99m Tc -N（NOEt）2, showed a definite value for liver carcinoma imaging of mice, the best timing of imaging was 120min,which suggests that ^99mTc N（NOEt）2 might be a new tracer for liver tumor imaging.
出处
《放射学实践》
2005年第9期826-829,共4页
Radiologic Practice
